Domina Emiliya A, Philchenkov Alex, Dubrovska Anna
Department of Biological Effects of Ionizing and Non-Ionizing Radiation, R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine.
Department of Oncohematology, R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine.
Crit Rev Oncog. 2018;23(1-2):69-92. doi: 10.1615/CritRevOncog.2018026308.
Radiation therapy remains one of the most effective cancer treatments. Nevertheless, biology-driven personalized radiation therapy that enables treatment according to the biological characteristics of the individual tumors and normal tissues still needs to be implemented in the clinic. Understanding the mechanisms of radiation response in both tumors and normal tissues is necessary to develop reliable predictive biomarkers for tumor radioresistance and normal tissue toxicity as well as to exploit new therapeutic opportunities for tumor radiosensitization. In this article, we review the mechanisms of tumor radiosensitivity as well as the early and late responses of normal tissues to therapeutic radiation exposure. We also discuss the possible implementation of these mechanisms for biology-driven personalized radiation treatment.
放射治疗仍然是最有效的癌症治疗方法之一。然而，根据个体肿瘤和正常组织的生物学特性进行治疗的生物学驱动的个性化放射治疗仍有待在临床上实施。了解肿瘤和正常组织中的辐射反应机制对于开发可靠的肿瘤放射抗性和正常组织毒性预测生物标志物以及探索肿瘤放射增敏的新治疗机会是必要的。在本文中，我们综述了肿瘤放射敏感性的机制以及正常组织对治疗性辐射暴露的早期和晚期反应。我们还讨论了这些机制在生物学驱动的个性化放射治疗中的可能应用。
