Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
Institute for Health Informatics, University of Minnesota, Minneapolis, MN, 55455, USA.
Immunity. 2018 Feb 20;48(2):327-338.e5. doi: 10.1016/j.immuni.2018.01.015.
Immunosurveillance of secondary lymphoid organs (SLO) is performed by central memory T cells that recirculate through blood. Resident memory T (Trm) cells remain parked in nonlymphoid tissues and often stably express CD69. We recently identified Trm cells within SLO, but the origin and phenotype of these cells remains unclear. Using parabiosis of "dirty" mice, we found that CD69 expression is insufficient to infer stable residence of SLO Trm cells. Restimulation of nonlymphoid memory CD8 T cells within the skin or mucosa resulted in a substantial increase in bona fide Trm cells specifically within draining lymph nodes. SLO Trm cells derived from emigrants from nonlymphoid tissues and shared some transcriptional and phenotypic signatures associated with nonlymphoid Trm cells. These data indicate that nonlymphoid cells can give rise to SLO Trm cells and suggest vaccination strategies by which memory CD8 T cell immunosurveillance can be regionalized to specific lymph nodes.
次级淋巴器官 (SLO) 的免疫监视由循环血液中的中央记忆 T 细胞执行。驻留记忆 T (Trm) 细胞停留在非淋巴组织中，并且通常稳定表达 CD69。我们最近在 SLO 中鉴定了 Trm 细胞，但这些细胞的起源和表型仍不清楚。通过“脏”小鼠的联体共生，我们发现 CD69 表达不足以推断 SLO Trm 细胞的稳定驻留。在皮肤或粘膜中的非淋巴记忆 CD8 T 细胞的再刺激导致真正的 Trm 细胞在引流淋巴结中大量增加。源自非淋巴组织的移民的 SLO Trm 细胞与非淋巴组织的 Trm 细胞相关的一些转录和表型特征共享。这些数据表明非淋巴细胞可以产生 SLO Trm 细胞，并提示通过这种策略可以将记忆 CD8 T 细胞的免疫监视区域化到特定的淋巴结。
