Rubel Rosalia, Santa Herta Stutz Dalla, Dos Santos Leandro Freire, Fernandes Luiz Claudio, Figueiredo Bonald Cavalcante, Soccol Carlos Ricardo
Bioprocess Engineering and Biotechnology Division, Federal University of Paraná, Curitiba, Paraná, Brazil.
Department of Pharmacy, Midwestern State University (UNICENTRO), Guarapuava, Paraná, Brazil.
Int J Med Mushrooms. 2018;20(4):393-403. doi: 10.1615/IntJMedMushrooms.2018025979.
Medicinal mushrooms are used in popular medicine largely as health promoters, mainly because of their antitumor and immunomodulatory activities. Ganoderma lucidum (lingzhi or reishi) and Agaricus brasiliensis are mushrooms that have long been used for medicinal purposes. This study evaluated their immunomodulatory and antitumor effects on mice fed a diet supplemented with G. lucidum and A. brasiliensis mycelia obtained from solid-state fermentation. For 14 weeks the mice were fed chow containing 50% A. brasiliensis and G. lucidum mycelia, using ground wheat as an excipient. The consumption of the supplemented diet inhibited Sarcoma 180 tumor growth and caused important changes in the immune system. The pattern of immune response shifted, increasing CD4+ and CD8+ and decreasing CD19+ cell populations. The restoration of a proper balance between cellular and humoral immunity is an essential process for restraining tumor growth. These results suggest that polysaccharides, such as β-glucans and other mushroom metabolites, possibly promote the T-cell dominance that is imperative to restrain tumor growth.
药用蘑菇在传统医学中主要被用作健康促进剂，主要是因为它们具有抗肿瘤和免疫调节活性。灵芝（lingzhi或reishi）和巴西蘑菇长期以来一直被用于药用。本研究评估了它们对喂食添加了通过固态发酵获得的灵芝和巴西蘑菇菌丝体饮食的小鼠的免疫调节和抗肿瘤作用。在14周内，给小鼠喂食含有50%巴西蘑菇和灵芝菌丝体的食物，使用磨碎的小麦作为辅料。补充饮食的摄入抑制了肉瘤180肿瘤的生长，并引起了免疫系统的重要变化。免疫反应模式发生了转变，CD4+和CD8+细胞群体增加，CD19+细胞群体减少。恢复细胞免疫和体液免疫之间的适当平衡是抑制肿瘤生长的关键过程。这些结果表明，多糖，如β-葡聚糖和其他蘑菇代谢产物，可能促进抑制肿瘤生长所必需的T细胞优势。
