Neuroscience and Cellular Biology Post Graduation Program, Institute of Biological Sciences, Federal University of Pará, Pará, Brazil.
Center for Research in Inflammatory Diseases (CRID), Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
Front Immunol. 2020 Jul 1;11:1238. doi: 10.3389/fimmu.2020.01238. eCollection 2020.
Sepsis is characterized by the host's dysregulated immune response to an infection followed by a potentially fatal organ dysfunction. Although there have been some advances in the treatment of sepsis, mainly focused on broad-spectrum antibiotics, mortality rates remain high, urging for the search of new therapies. Oxidative stress is one of the main features of septic patients, so antioxidants can be a good alternative treatment. is a nutraceutical rich in bioactive compounds such as polyphenols and polysaccharides, exhibiting antioxidant, antitumor, and immunomodulatory activities. Here, we investigated the immunomodulatory and antioxidant effects of aqueous extract in the cecal ligation and puncture (CLP) sepsis model. Our data showed that aqueous extract of reduced systemic inflammatory response and improved bacteria clearance and mice survival. In addition, decreased the oxidative stress markers in serum, peritoneal cavity, heart and liver of septic animals, as well as ROS production ( and ) and -Butyl hydroperoxide-induced DNA damage in peripheral blood mononuclear cells from healthy donors . In conclusion, the aqueous extract of was able to increase the survival of septic animals by a mechanism involving immunomodulatory and antioxidant protective effects.
脓毒症的特征是宿主对感染的免疫反应失调，随后可能导致器官功能障碍甚至死亡。尽管在脓毒症的治疗方面已经取得了一些进展，主要集中在广谱抗生素上，但死亡率仍然很高，因此迫切需要寻找新的治疗方法。氧化应激是脓毒症患者的主要特征之一，因此抗氧化剂可能是一种很好的替代治疗方法。 是一种富含生物活性化合物的营养保健品，如多酚和多糖，具有抗氧化、抗肿瘤和免疫调节作用。在这里，我们研究了 水提物在盲肠结扎和穿刺（CLP）脓毒症模型中的免疫调节和抗氧化作用。我们的数据表明， 水提物降低了全身性炎症反应，提高了细菌清除率和小鼠存活率。此外， 降低了脓毒症动物血清、腹腔、心脏和肝脏中的氧化应激标志物，以及健康供体外周血单个核细胞中 ROS 产生（ 和 ）和 -Butyl hydroperoxide 诱导的 DNA 损伤 。总之， 水提物通过免疫调节和抗氧化保护作用增加了脓毒症动物的存活率。
