Istituto Superiore di Sanità, Viale Regina Elena 299, 00166 Roma, Italy.
Toxicol Lett. 2018 Dec 1;298:25-32. doi: 10.1016/j.toxlet.2018.06.1215. Epub 2018 Jun 25.
Although high or repeated exposure to different forms of Hg can have serious health consequences, the most important toxicity risk for humans is as methylmercury (MeHg) which exposure is mainly through consumption of fish. Generally, more than the 80% of Hg in hair is as MeHg, which is taken up by hair follicles as MeHg-cysteine complexes. In this context, hair samples were collected from 200 children (7 years) living in a coastal site in the North-East (A) of Italy and from 299 children (6-11 years) living in a urban area of South of Italy (B) to determine the levels of MeHg. Considering the neurotoxicity of MeHg, children were subjected to cognitive and neuropsychological tests. The hair values of Hg in the children population groups were comparable with data reported in other international surveys. On the other hand, combining results of the neurological tests with Hg levels, a possible relationship between Hg and an increase of the errors average reported in some neurological tests has been noted. Although the Hg levels were not elevated, a possible neurological influence in children, a population more susceptible than adults, might not be excluded, but the influence on neurological performances of the children could be also due to the family environment (socio economic status, educational level, etc.).
虽然高浓度或反复接触不同形式的汞会对健康造成严重后果,但对人类最重要的毒性风险是甲基汞(MeHg),其暴露主要通过食用鱼类。一般来说,头发中超过 80%的汞以 MeHg 的形式存在,MeHg 作为 MeHg-半胱氨酸复合物被毛囊吸收。在这种情况下,从意大利东北部沿海地区(A 组)的 200 名 7 岁儿童和意大利南部城市地区(B 组)的 299 名 6-11 岁儿童采集了头发样本,以确定 MeHg 的水平。考虑到 MeHg 的神经毒性,对儿童进行了认知和神经心理学测试。儿童群体的头发汞值与其他国际调查报告的数据相当。另一方面,将神经测试的结果与 Hg 水平相结合,注意到 Hg 与一些神经测试中报告的错误平均值增加之间可能存在关系。尽管 Hg 水平没有升高,但不能排除 Hg 对儿童(比成年人更敏感的人群)的可能的神经影响,但儿童的神经行为表现的影响也可能归因于家庭环境(社会经济地位、教育水平等)。