Zhu Xinwei, Zhong Yu, Xie Zihui, Wu Manlin, Hu Zhibo, Ding Weijia, Li Chunyuan
College of Materials and Energy, South China Agricultural University, Guangzhou, China.
Planta Med. 2018 Dec;84(18):1355-1362. doi: 10.1055/a-0647-7048. Epub 2018 Jun 28.
Two novel cyclic hexadepsipeptides, fusarihexin A (1: ) and fusarihexin B (2: ), and two known compounds, cyclo-(L-Leu-L-Leu-D-Leu-L-Leu-L-Val) (3: ) and cyclo-(L-Leu-L-Leu-D-Leu-L-Leu-L-Ile) (4: ), were isolated from the marine mangrove endophytic fungus sp. R5. Their chemical structures were elucidated on the basis of spectroscopic data and Marfey's analysis. In an bioassay, fusarihexin A (1: ) remarkably inhibited three plant pathogenic fungi: (Penz.) Sacc., which causes anthracnose in many fruits and vegetables, (Berk. and M. A. Curtis) Arx, which causes crown rot and anthracnose in bananas, and Schlecht. f. sp. lycopersici (Sacc.) W. C. Snyder et H. N. Hansen, which causes Fusarium wilt and fruit rot in tomatoes. Fusarihexin B (2: ) strongly inhibited and . The compounds were more potent than carbendazim, which is widely used as an agricultural and horticultural fungicide worldwide.
从海洋红树林内生真菌镰刀菌属R5中分离出两种新型环状六肽缩酚酸肽，镰刀菌素A（1： ）和镰刀菌素B（2： ），以及两种已知化合物，环（L-亮氨酸-L-亮氨酸-D-亮氨酸-L-亮氨酸-L-缬氨酸）（3： ）和环（L-亮氨酸-L-亮氨酸-D-亮氨酸-L-亮氨酸-L-异亮氨酸）（4： ）。基于光谱数据和马尔菲分析阐明了它们的化学结构。在体外生物测定中，镰刀菌素A（1： ）显著抑制三种植物病原真菌：引起许多水果和蔬菜炭疽病的胶孢炭疽菌（Penz.）Sacc.、引起香蕉冠腐病和炭疽病的尖孢炭疽菌（Berk.和M.A. Curtis）Arx，以及引起番茄枯萎病和果实腐烂的番茄枯萎病菌Schlecht. f. sp. lycopersici（Sacc.）W.C. Snyder et H.N. Hansen。镰刀菌素B（2： ）强烈抑制胶孢炭疽菌和尖孢炭疽菌。这些化合物比多菌灵更有效，多菌灵在全球范围内广泛用作农业和园艺杀菌剂。
