• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Mutational screening of newly diagnosed multiple myeloma patients by deep targeted sequencing.通过深度靶向测序对新诊断的多发性骨髓瘤患者进行突变筛查。
Haematologica. 2018 Nov;103(11):e544-e548. doi: 10.3324/haematol.2018.188839. Epub 2018 Jun 28.
2
The molecular spectrum and clinical impact of DIS3 mutations in multiple myeloma.多发性骨髓瘤中DIS3突变的分子光谱及临床影响
Br J Haematol. 2015 Apr;169(1):57-70. doi: 10.1111/bjh.13256. Epub 2014 Dec 17.
3
Mutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma.突变谱、拷贝数变化与预后：新诊断骨髓瘤患者测序研究结果
J Clin Oncol. 2015 Nov 20;33(33):3911-20. doi: 10.1200/JCO.2014.59.1503. Epub 2015 Aug 17.
4
Impact of Fc gamma receptor polymorphisms on efficacy and safety of daratumumab in relapsed/refractory multiple myeloma.Fcγ受体基因多态性对达雷妥尤单抗治疗复发/难治性多发性骨髓瘤疗效及安全性的影响
Br J Haematol. 2019 Feb;184(3):475-479. doi: 10.1111/bjh.15122. Epub 2018 Feb 7.
5
Inherited variation in the xenobiotic transporter pathway and survival of multiple myeloma patients.异生物转运途径中的遗传变异与多发性骨髓瘤患者的生存。
Br J Haematol. 2018 Nov;183(3):375-384. doi: 10.1111/bjh.15521. Epub 2018 Aug 6.
6
A Next-Generation Sequencing Strategy for Evaluating the Most Common Genetic Abnormalities in Multiple Myeloma.一种用于评估多发性骨髓瘤中最常见基因异常的新一代测序策略。
J Mol Diagn. 2017 Jan;19(1):99-106. doi: 10.1016/j.jmoldx.2016.08.004. Epub 2016 Nov 15.
7
Analytical and clinical validation of a novel in-house deep-sequencing method for minimal residual disease monitoring in a phase II trial for multiple myeloma.一种用于多发性骨髓瘤II期试验中微小残留病监测的新型内部深度测序方法的分析和临床验证。
Leukemia. 2017 Jun;31(6):1446-1449. doi: 10.1038/leu.2017.58. Epub 2017 Feb 17.
8
IRF4 in multiple myeloma-Biology, disease and therapeutic target.多发性骨髓瘤中的IRF4——生物学、疾病与治疗靶点
Leuk Res. 2018 Sep;72:52-58. doi: 10.1016/j.leukres.2018.07.025. Epub 2018 Aug 3.
9
Panel sequencing for clinically oriented variant screening and copy number detection in 142 untreated multiple myeloma patients.对142例未经治疗的多发性骨髓瘤患者进行临床导向的变异筛查和拷贝数检测的基因panel测序。
Blood Cancer J. 2016 Feb 26;6(2):e397. doi: 10.1038/bcj.2016.1.
10
MB4-2 breakpoint in MMSET combined with del(17p) defines a subset of t(4;14) multiple myeloma with very poor prognosis.MMSET基因中的MB4-2断点与17p缺失相结合，定义了一组预后极差的t(4;14)多发性骨髓瘤。
Haematologica. 2015 Nov;100(11):e471-4. doi: 10.3324/haematol.2015.127001. Epub 2015 Jul 23.

引用本文的文献

1
NGS-Based Molecular Karyotyping of Multiple Myeloma: Results from the GEM12 Clinical Trial.基于二代测序的多发性骨髓瘤分子核型分析：GEM12临床试验结果
Cancers (Basel). 2022 Oct 21;14(20):5169. doi: 10.3390/cancers14205169.
2
Comparison of Clinical Characteristics and Genetic Aberrations of Plasma Cell Disorders in Thailand Population.中泰两国浆细胞疾病的临床特征和遗传学异常比较。
Technol Cancer Res Treat. 2022 Jan-Dec;21:15330338221111228. doi: 10.1177/15330338221111228.
3
The Dynamics of Nucleotide Variants in the Progression from Low-Intermediate Myeloma Precursor Conditions to Multiple Myeloma: Studying Serial Samples with a Targeted Sequencing Approach.从低中级骨髓瘤前驱状态进展至多发性骨髓瘤过程中核苷酸变异的动态变化：采用靶向测序方法研究系列样本
Cancers (Basel). 2022 Feb 18;14(4):1035. doi: 10.3390/cancers14041035.
4
Genome Instability in Multiple Myeloma: Facts and Factors.多发性骨髓瘤中的基因组不稳定：事实与因素
Cancers (Basel). 2021 Nov 26;13(23):5949. doi: 10.3390/cancers13235949.
5
Cereblon enhancer methylation and IMiD resistance in multiple myeloma.多发性骨髓瘤中 cereblon 增强子甲基化和 IMiD 耐药性。
Blood. 2021 Nov 4;138(18):1721-1726. doi: 10.1182/blood.2020010452.
6
Genetic Abnormalities in Multiple Myeloma: Prognostic and Therapeutic Implications.多发性骨髓瘤中的遗传异常：预后和治疗意义。
Cells. 2021 Feb 5;10(2):336. doi: 10.3390/cells10020336.
7
Multiple myeloma with central nervous system relapse.多发性骨髓瘤伴中枢神经系统复发。
Haematologica. 2020 Jul;105(7):1780-1790. doi: 10.3324/haematol.2020.248518. Epub 2020 May 15.
8
RAS/RAF mutations in tumor samples and cell-free DNA from plasma and bone marrow aspirates in multiple myeloma patients.多发性骨髓瘤患者肿瘤样本以及血浆和骨髓穿刺液中游离DNA的RAS/RAF突变
J Cancer. 2020 Mar 15;11(12):3543-3550. doi: 10.7150/jca.43729. eCollection 2020.
9
Germline CDKN1B Loss-of-Function Variants Cause Pediatric Cushing's Disease With or Without an MEN4 Phenotype.胚系 CDKN1B 功能丧失性变异导致儿童库欣病伴或不伴 MEN4 表型。
J Clin Endocrinol Metab. 2020 Jun 1;105(6):1983-2005. doi: 10.1210/clinem/dgaa160.
10
CIC Mutation as a Molecular Mechanism of Acquired Resistance to Combined BRAF-MEK Inhibition in Extramedullary Multiple Myeloma with Central Nervous System Involvement.CIC 突变作为中枢神经系统累及髓外多发性骨髓瘤对 BRAF-MEK 联合抑制获得性耐药的分子机制。
Oncologist. 2020 Feb;25(2):112-118. doi: 10.1634/theoncologist.2019-0356. Epub 2019 Oct 18.

本文引用的文献

1
A DNA target-enrichment approach to detect mutations, copy number changes and immunoglobulin translocations in multiple myeloma.一种用于检测多发性骨髓瘤中突变、拷贝数变化和免疫球蛋白易位的DNA靶向富集方法。
Blood Cancer J. 2016 Sep 2;6(9):e467. doi: 10.1038/bcj.2016.72.
2
Targeted sequencing of refractory myeloma reveals a high incidence of mutations in CRBN and Ras pathway genes.难治性骨髓瘤的靶向测序显示CRBN和Ras信号通路基因的突变发生率很高。
Blood. 2016 Sep 1;128(9):1226-33. doi: 10.1182/blood-2016-02-698092. Epub 2016 Jul 25.
3
Panel sequencing for clinically oriented variant screening and copy number detection in 142 untreated multiple myeloma patients.对142例未经治疗的多发性骨髓瘤患者进行临床导向的变异筛查和拷贝数检测的基因panel测序。
Blood Cancer J. 2016 Feb 26;6(2):e397. doi: 10.1038/bcj.2016.1.
4
Sequential vs alternating administration of VMP and Rd in elderly patients with newly diagnosed MM.老年初诊 MM 患者中 VMP 与 Rd 序贯与交替给药的比较。
Blood. 2016 Jan 28;127(4):420-5. doi: 10.1182/blood-2015-08-666537. Epub 2015 Oct 23.
5
Mutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma.突变谱、拷贝数变化与预后：新诊断骨髓瘤患者测序研究结果
J Clin Oncol. 2015 Nov 20;33(33):3911-20. doi: 10.1200/JCO.2014.59.1503. Epub 2015 Aug 17.
6
Longitudinal analysis of 25 sequential sample-pairs using a custom multiple myeloma mutation sequencing panel (M(3)P).使用定制的多发性骨髓瘤突变测序面板（M(3)P）对25个连续样本对进行纵向分析。
Ann Hematol. 2015 Jul;94(7):1205-11. doi: 10.1007/s00277-015-2344-9. Epub 2015 Mar 7.
7
Targeted sequencing using a 47 gene multiple myeloma mutation panel (M(3) P) in -17p high risk disease.采用 47 基因多发性骨髓瘤突变 panel（M(3) P）对高危-17p 疾病进行靶向测序。
Br J Haematol. 2015 Feb;168(4):507-10. doi: 10.1111/bjh.13171. Epub 2014 Oct 10.
8
Identification of cereblon-binding proteins and relationship with response and survival after IMiDs in multiple myeloma.多发性骨髓瘤中cereblon结合蛋白的鉴定及其与免疫调节药物治疗反应和生存的关系。
Blood. 2014 Jul 24;124(4):536-45. doi: 10.1182/blood-2014-02-557819. Epub 2014 Jun 9.
9
Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy.多发性骨髓瘤的广泛遗传异质性：对靶向治疗的影响。
Cancer Cell. 2014 Jan 13;25(1):91-101. doi: 10.1016/j.ccr.2013.12.015.
10
Heterogeneity of genomic evolution and mutational profiles in multiple myeloma.多发性骨髓瘤中基因组进化和突变谱的异质性
Nat Commun. 2014;5:2997. doi: 10.1038/ncomms3997.

Mutational screening of newly diagnosed multiple myeloma patients by deep targeted sequencing.

作者信息

Ruiz-Heredia Yanira, Sánchez-Vega Beatriz, Onecha Esther, Barrio Santiago, Alonso Rafael, Martínez-Ávila Jose Carlos, Cuenca Isabel, Agirre Xabier, Braggio Esteban, Hernández Miguel-T, Martínez Rafael, Rosiñol Laura, Gutierrez Norma, Martin-Ramos Marisa, Ocio Enrique M, Echeveste María-Asunción, de Oteyza Jaime Pérez, Oriol Albert, Bargay Joan, Gironella Mercedes, Ayala Rosa, Bladé Joan, Mateos María-Victoria, Kortum Klaus M, Stewart Keith, García-Sanz Ramón, Miguel Jesús San, Lahuerta Juan José, Martinez-Lopez Joaquín

机构信息

Department of Hematology, Hospital Universitario 12 de Octubre-Hematological Malignancies Clinical Research Unit H120-CNIO, Madrid, Spain.

Department of Internal Medicine II, University Hospital Würzburg, Germany.

出版信息

Haematologica. 2018 Nov;103(11):e544-e548. doi: 10.3324/haematol.2018.188839. Epub 2018 Jun 28.

DOI:10.3324/haematol.2018.188839
PMID:29954938
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6278988/
Abstract
摘要