Monash Alfred Psychiatry Research Centre (MAPrc), Central Clinical School, Monash University and The Alfred Hospital, Melbourne, Victoria, Australia.
Transl Psychiatry. 2018 Jun 28;8(1):123. doi: 10.1038/s41398-018-0172-0.
The menopause transition is a time when women experience an increased risk for new onset depression, as well as relapse of depression. While there are overlapping symptoms between major depression and depression during menopause, differences suggest 'perimenopausal depression' may be a unique subtype of depression associated with characteristic symptoms. There is currently no validated scale designed to measure perimenopausal depression. The aim of the current study was to develop and validate the 'Meno-D', a self-reporting or clinician rated questionnaire, designed to rate the severity of symptoms of perimenopausal depression. The development phase of the Meno-D involved literature review, clinical observation, and focus groups. A 12-item questionnaire was developed and clinically reviewed for face validity for content. The Meno-D was administered to women experiencing symptoms of perimenopausal depression as part of a larger baseline assessment battery. Validation involved confirmatory factor analysis (CFA). The development of the Meno-D resulted in 12 items. A total of 93 participants with perimenopausal depression were involved in the baseline assessments, 82 completed the Meno-D. Factor analysis identified five sub-scales of the Meno-D "somatic; cognitive; self; sleep; sexual" with high-internal consistency; discriminant validity and a good construct and convergent validity. The Meno-D provides a unique tool for clinicians and researchers to measure the presence of perimenopausal depression.
更年期过渡时期是女性新发性抑郁症以及抑郁症复发风险增加的时期。虽然重度抑郁症和更年期抑郁症之间存在重叠症状，但差异表明“围绝经期抑郁症”可能是一种与特征性症状相关的独特的抑郁症亚型。目前还没有专门设计用来衡量围绝经期抑郁症的验证量表。本研究的目的是开发和验证“Meno-D”，这是一种自我报告或临床医生评定问卷，旨在评估围绝经期抑郁症症状的严重程度。Meno-D 的开发阶段涉及文献回顾、临床观察和焦点小组。开发了一个 12 项的问卷，并对其内容的表面效度进行了临床审查。Meno-D 被用于经历围绝经期抑郁症症状的女性，作为更大的基线评估工具包的一部分。验证涉及验证性因素分析 (CFA)。Meno-D 的开发产生了 12 个项目。共有 93 名患有围绝经期抑郁症的参与者参与了基线评估，其中 82 名完成了 Meno-D。因素分析确定了 Meno-D 的五个子量表：“躯体；认知；自我；睡眠；性”，具有较高的内部一致性；判别有效性以及良好的结构和收敛有效性。Meno-D 为临床医生和研究人员提供了一种独特的工具来衡量围绝经期抑郁症的存在。
