Behrman Sophie, Crockett Clair
Oxford Health NHS Foundation Trust, UK.
Newson Health Menopause and Wellbeing Centre, UK.
BJPsych Bull. 2023 Nov 13;48(6):1-7. doi: 10.1192/bjb.2023.89.
Hormonal fluctuations in the perimenopause are associated with an array of physical and psychological symptoms. Those with pre-existing mental disorders may experience changes to their symptoms and response to treatment during the perimenopausal and postmenopausal periods and may also be at risk of poorer longer-term physical health outcomes in menopause. The transition towards menopause may be compounded by the oestradiol-suppressing effect of many psychotropics on the hypothalamopituitary-gonadal axis. A collaborative approach between primary care and secondary mental health services is an opportunity for proactive discussion of symptoms and support with management of the perimenopause. This may involve lifestyle measures and/or hormone replacement therapy, which can both lead to improvements in well-being and mental and physical health.
围绝经期的激素波动与一系列身体和心理症状相关。那些患有既往精神障碍的人在围绝经期和绝经后期可能会经历症状变化以及对治疗的反应变化，并且在绝经后可能还面临长期身体健康状况较差的风险。许多精神药物对下丘脑 - 垂体 - 性腺轴的雌二醇抑制作用可能会使向绝经的过渡更加复杂。初级保健和二级心理健康服务之间的协作方法为积极讨论围绝经期症状以及提供管理支持提供了契机。这可能涉及生活方式措施和/或激素替代疗法，两者都可以改善幸福感以及身心健康。
