Aonuma Hitoshi, Totani Yuki, Sakakibara Manabu, Lukowiak Ken, Ito Etsuro
Research Center of Mathematics for Social Creativity, Research Institute for Electronic Science, Hokkaido University, Sapporo, Hokkaido 060-0811, Japan.
CREST, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan.
Biophys Physicobiol. 2018 May 16;15:129-135. doi: 10.2142/biophysico.15.0_129. eCollection 2018.
To find a causal mechanism of learning and memory is a heuristically important topic in neuroscience. In the pond snail , the following experimental facts have accrued regarding a classical conditioning procedure known as conditioned taste aversion (CTA): (1) one-day food-deprived Dutch snails have superior CTA memory formation; (2) the one-day food-deprived snails have a low monoamine content (e.g., serotonin, dopamine, octopamine) in their central nervous system (CNS); (3) fed or five-day food-deprived snails have poorer CTA memory and a higher monoamine content; (4) the Dutch snails form better CTA memory than the Canadian TC1 strain; and, (5) the F cross snails between the Dutch and Canadian TC1 strains also form poor CTA memory. Here, in one-day food-deprived snails, we measured the monoamine content in the CNSs of the 3 populations. In most instances, the monoamine content of the Dutch strain was lower than in the other two populations. The F cross snails had the highest monoamine content. A lower monoamine content is correlated with the better CTA memory formation.
寻找学习与记忆的因果机制是神经科学中一个具有启发式重要意义的课题。在池塘蜗牛中，关于一种被称为条件性味觉厌恶（CTA）的经典条件作用程序，已经积累了以下实验事实：（1）禁食一天的荷兰蜗牛具有更优的CTA记忆形成能力；（2）禁食一天的蜗牛其中枢神经系统（CNS）中的单胺含量较低（例如血清素、多巴胺、章鱼胺）；（3）喂食后的或禁食五天的蜗牛具有较差的CTA记忆且单胺含量较高；（4）荷兰蜗牛比加拿大TC1品系形成更好的CTA记忆；以及，（5）荷兰和加拿大TC1品系之间的F杂交蜗牛也形成较差的CTA记忆。在此，我们测量了禁食一天的蜗牛中三个群体中枢神经系统中的单胺含量。在大多数情况下，荷兰品系的单胺含量低于其他两个群体。F杂交蜗牛的单胺含量最高。较低的单胺含量与更好的CTA记忆形成相关。
