Bone Density Research Laboratory, Department of Health and Exercise Science, University of Oklahoma, 1401 Asp Avenue, Norman, OK, 73019, USA.
Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, University of Colorado at Denver Anschutz Medical Campus, Aurora, CO, 80045, USA.
J Bone Miner Metab. 2019 Mar;37(2):358-367. doi: 10.1007/s00774-018-0933-0. Epub 2018 Jun 28.
Whole-body vibration (WBV) has been shown to improve bone mineral density, and muscle strength and power. No studies to date have examined sclerostin and parathyroid hormone (PTH) responses to WBV combined with resistance exercise (RE). This randomized crossover study compared acute serum sclerostin and PTH responses to RE and WBV + RE in young women (n = 9) taking oral contraceptives. Participants were exposed to 5 1-min bouts of vibration (20 Hz, 3.38 peak-peak displacement, separated by 1 min of rest) before high intensity resistance exercise. Fasting blood samples were obtained before (PRE), immediately after WBV (POSTWBV), immediately post RE (IP) and 30 min post RE (30P). Pre-exercise sclerostin and PTH levels were not significantly different between conditions. Sclerostin levels significantly (p < 0.05) increased from PRE to IP for the WBV + RE condition, then decreased back to the pre-exercise level. PTH significantly decreased from PRE to 30P (p < 0.05) and IP to 30P (p < 0.01) for both conditions. Correcting for hemoconcentration eliminated the significant sclerostin responses, but the significant decrease in PTH remained (p < 0.05). There were no significant relationships found between sclerostin and PTH. In conclusion, sclerostin concentrations increased in response to the WBV + RE condition, which may have been mediated by plasma volume shifts. There was no transient PTH increase, but it showed a large decrease at 30P for both conditions. Based on these findings, the addition of WBV exposures prior to high intensity RE did not alter sclerostin and PTH responses to RE in young women.
全身振动（WBV）已被证明可提高骨密度和肌肉力量和功率。迄今为止，尚无研究探讨过骨硬化蛋白和甲状旁腺激素（PTH）对 WBV 联合抗阻运动（RE）的反应。这项随机交叉研究比较了口服避孕药的年轻女性在接受 RE 和 WBV+RE 后，血清骨硬化蛋白和 PTH 的急性反应。参与者在高强度抗阻运动前接受了 5 次 1 分钟的振动（20Hz，3.38 峰峰值位移，间隔 1 分钟休息）。空腹血样在 WBV 前（PRE）、WBV 后即刻（POSTWBV）、RE 后即刻（IP）和 RE 后 30 分钟（30P）时采集。在两种情况下，PRE 时的骨硬化蛋白和 PTH 水平没有明显差异。骨硬化蛋白水平在 WBV+RE 条件下从 PRE 到 IP 显著增加（p<0.05），然后恢复到 PRE 水平。两种情况下，PTH 均从 PRE 下降至 30P（p<0.05）和 IP 至 30P（p<0.01）。纠正血液浓缩消除了骨硬化蛋白的显著反应，但 PTH 的显著下降仍然存在（p<0.05）。未发现骨硬化蛋白和 PTH 之间存在显著关系。总之，骨硬化蛋白浓度对 WBV+RE 条件呈反应性增加，这可能是通过血浆容量转移介导的。没有出现短暂的 PTH 增加，但两种情况下 30P 时均出现大幅下降。基于这些发现，在高强度 RE 之前增加 WBV 暴露并没有改变年轻女性对 RE 的骨硬化蛋白和 PTH 反应。
