Cancer Metastasis Alert and Prevention Center, and Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry; Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, Fujian 350116, China.
Curr Cancer Drug Targets. 2019;19(4):257-276. doi: 10.2174/1568009618666180628160211.
Effective cancer therapy is still a great challenge for modern medical research due to the complex underlying mechanisms of tumorigenesis and tumor metastasis, and the limitations commonly associated with currently used cancer therapeutic options. Nanotechnology has been implemented in cancer therapeutics with immense potential for improving cancer treatment.
Through information about the recent advances regarding cancer hallmarks, we could comprehensively understand the pharmacological effects and explore the mechanisms of the interaction between the nanomaterials, which could provide opportunities to develop mechanism-based nanomedicine to treat human cancers.
We collected related information and data from articles.
In this review, we discussed the characteristics of cancer including tumor angiogenesis, abnormalities in tumor blood vessels, uncontrolled cell proliferation markers, multidrug resistance, tumor metastasis, cancer cell metabolism, and tumor immune system that provide opportunities and challenges for nanomedicine to be directed to specific cancer cells and portray the progress that has been accomplished in application of nanotechnology for cancer treatment.
The information presented in this review can provide useful references for further studies on developing effective nanomedicine for the treatment of cancer.
由于肿瘤发生和转移的复杂潜在机制，以及目前常用的癌症治疗方法的局限性，有效的癌症治疗仍然是现代医学研究的一大挑战。纳米技术已应用于癌症治疗，具有改善癌症治疗的巨大潜力。
通过有关癌症标志的最新进展的信息，我们可以全面了解药理作用，并探讨纳米材料相互作用的机制，这为开发基于机制的纳米医学治疗人类癌症提供了机会。
我们从文章中收集了相关信息和数据。
在这篇综述中，我们讨论了癌症的特征，包括肿瘤血管生成、肿瘤血管异常、失控的细胞增殖标志物、多药耐药性、肿瘤转移、癌细胞代谢和肿瘤免疫系统，这些特征为纳米医学靶向特定癌细胞提供了机会和挑战，并描述了在应用纳米技术治疗癌症方面所取得的进展。
本文提供的信息可为开发有效的癌症治疗纳米医学提供有用的参考。
