Qinba State Key Laboratory of Biological Resources and Ecological Environment, 2011 QinLing-Bashan Mountains Bioresources Comprehensive Development C. I. C., Shaanxi Province Key Laboratory of Bio-Resources, College of Bioscience and Bioengineering, Shaanxi University of Technology, Hanzhong 723001, China.
Department of Clinical Sciences, d Centre of Medical and Bio-Allied Health Sciences and Research, College of Dentistry, Ajman University, Ajman P.O. Box 346, United Arab Emirates.
Molecules. 2024 Jun 6;29(11):2706. doi: 10.3390/molecules29112706.
The fabrication of zinc oxide-based nanomaterials (including natural and synthetic polymers like sulfated polysaccharide, chitosan, and polymethyl methacrylate) has potential to improve oral cancer treatment strategies. This comprehensive review explores the diverse synthesis methods employed to fabricate zinc oxide nanomaterials tailored for oral cancer applications. Several synthesis processes, particularly sol-gel, hydrothermal, and chemical vapor deposition approaches, are thoroughly studied, highlighting their advantages and limitations. The review also examines how synthesis parameters, such as precursor selection, the reaction temperature, and growth conditions, influence both the physicochemical attributes and biological efficacy of the resulting nanomaterials. Furthermore, recent advancements in surface functionalization and modification strategies targeted at improving the targeting specificity and pharmaceutical effectiveness of zinc oxide-based nanomaterials in oral cancer therapy are elucidated. Additionally, the review provides insights into the existing issues and prospective views in the field, emphasizing the need for further research to optimize synthesis methodologies and elucidate the mechanisms underlying the efficacy of zinc oxide-based nanoparticles in oral cancer therapy.
氧化锌基纳米材料（包括天然和合成聚合物，如硫酸多糖、壳聚糖和聚甲基丙烯酸甲酯）的制造有潜力改善口腔癌治疗策略。本综述探讨了用于口腔癌应用的氧化锌纳米材料的各种合成方法。几种合成工艺，特别是溶胶-凝胶、水热和化学气相沉积方法，得到了深入研究，强调了它们的优点和局限性。本综述还研究了合成参数（如前体选择、反应温度和生长条件）如何影响所得纳米材料的物理化学性质和生物功效。此外，还阐述了表面功能化和修饰策略的最新进展，旨在提高基于氧化锌的纳米材料在口腔癌治疗中的靶向特异性和药物有效性。此外，该综述还提供了该领域现有问题和前瞻性观点的见解，强调需要进一步研究以优化合成方法，并阐明基于氧化锌纳米粒子在口腔癌治疗中的疗效的机制。
