Lewis Thomas G, Nydorf Ethan D
Department of Dermatology, Henry Ford Hospital, Detroit, MI 48202, USA.
J Drugs Dermatol. 2006 Jun;5(6):499-504.
Intralesional bleomycin has been used for the treatment of warts since the 1970s. Currently, there is a limited amount of evidence from randomized placebo-controlled trials comparing intralesional bleomycin with other local treatments for warts. Numerous reports have been published on the use of intralesional bleomycin for the treatment of recalcitrant warts with cure rates ranging from 14% to 99%. The majority of the data suggests that bleomycin is effective in over two-thirds of the reported cases with minimal side effects. In this paper, we review the mechanism of action, pharmacokinetics, safety profile, supply and storage, dosage scheme, techniques for administration, and efficacy of intralesional bleomycin for the treatment of warts.
自20世纪70年代以来，博来霉素皮损内注射一直用于治疗疣。目前，关于博来霉素皮损内注射与其他疣局部治疗方法比较的随机安慰剂对照试验的证据有限。已有大量关于使用博来霉素皮损内注射治疗顽固性疣的报告，治愈率在14%至99%之间。大多数数据表明，博来霉素在超过三分之二的报告病例中有效，且副作用极小。在本文中，我们综述了博来霉素皮损内注射治疗疣的作用机制、药代动力学、安全性、供应与储存、给药方案、给药技术及疗效。
