人类X染色体的分子遗传学
Molecular genetics of the human X chromosome.
作者信息
Davies K E
出版信息
J Med Genet. 1985 Aug;22(4):243-9. doi: 10.1136/jmg.22.4.243.
Abstract
The human X chromosome will soon be mapped at 10 cM intervals. This will permit the localisation of any X linked disorder provided that informative families are available for linkage analysis. The location of RFLPs currently in use for clinical diagnosis is summarised. The next decade should witness the elucidation of the molecular basis of some of the more common defects, such as the muscular dystrophies and X linked mental retardation.
摘要
人类X染色体很快将以10厘摩的间隔进行图谱绘制。这将能够定位任何X连锁疾病，前提是有提供信息的家系可用于连锁分析。总结了目前用于临床诊断的限制性片段长度多态性（RFLP）的位置。未来十年应该能够阐明一些更常见缺陷的分子基础，比如肌肉萎缩症和X连锁智力迟钝。
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本文引用的文献
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Linkage of genes for chronic granulomatous disease and Xg.慢性肉芽肿病基因与Xg血型的连锁关系
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Chiasma derived genetic maps and recombination fractions: chromosome 1.交叉衍生的遗传图谱和重组率：第1号染色体
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Localization of the human insulin gene to the distal end of the short arm of chromosome 11.人类胰岛素基因定位于11号染色体短臂的末端。
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Isolation of a genomic clone partially encoding human hypoxanthine phosphoribosyltransferase.部分编码人次黄嘌呤磷酸核糖基转移酶的基因组克隆的分离
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Cloned cDNA sequences of the hypoxanthine/guanine phosphoribosyltransferase gene from a mouse neuroblastoma cell line found to have amplified genomic sequences.从小鼠神经母细胞瘤细胞系中克隆出次黄嘌呤/鸟嘌呤磷酸核糖转移酶基因的cDNA序列，该细胞系被发现具有扩增的基因组序列。
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Expression of an X-linked gene from an inactive human X chromosome in mouse-human hybrid cells: further evidence for the noninactivation of the steroid sulfatase locus in man.人类X染色体失活状态下X连锁基因在人-鼠杂交细胞中的表达：关于人类类固醇硫酸酯酶基因座未失活的进一步证据
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Isolation and localization of DNA segments from specific human chromosomes.从特定人类染色体中分离和定位DNA片段。
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