卡马西泮在大鼠和小鼠体内的分布。

Distribution of camazepam in rats and mice.

作者信息

Marcucci F, Mussini E, Cotellessa L, Ghirardi P, Parenti M, Riva R, Salva P

出版信息

J Pharm Sci. 1978 Oct;67(10):1470-1. doi: 10.1002/jps.2600671041.

Abstract

Camazepam, 5 mg/kg iv, was injected in rats and mice to study its distribution in the blood and brain. Peak blood levels were about 0.9 microgram/ml in rats and 0.6 microgram/ml in mice. Peak brain levels were about 1.5 microgram/g in rats and 0.8 microgram/g in mice. The apparent blood half-life of camazepam was 9 min in mice and 20 min in rats.

摘要

给大鼠和小鼠静脉注射5毫克/千克的卡马西泮，以研究其在血液和大脑中的分布。大鼠的血药峰值约为0.9微克/毫升，小鼠为0.6微克/毫升。大鼠的脑药峰值约为1.5微克/克，小鼠为0.8微克/克。卡马西泮在小鼠体内的表观血液半衰期为9分钟，在大鼠体内为20分钟。