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Let's Talk about Sex: A Novel Mechanism by Which Estrogen Receptor β Limits Hypoxia-Inducible Factor Expression in Pulmonary Endothelial Cells.

作者信息

Shimoda Larissa A

机构信息

1 Division of Pulmonary and Critical Care Medicine Johns Hopkins School of Medicine Baltimore, Maryland.

出版信息

Am J Respir Cell Mol Biol. 2018 Jul;59(1):11-12. doi: 10.1165/rcmb.2018-0030ED.

DOI:10.1165/rcmb.2018-0030ED
PMID:29957049
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6039873/
Abstract
摘要

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本文引用的文献

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Hypoxia Upregulates Estrogen Receptor β in Pulmonary Artery Endothelial Cells in a HIF-1α-Dependent Manner.低氧以依赖 HIF-1α 的方式在上皮细胞中上调雌激素受体 β。
Am J Respir Cell Mol Biol. 2018 Jul;59(1):114-126. doi: 10.1165/rcmb.2017-0167OC.
2
Role of the Aryl Hydrocarbon Receptor in Sugen 5416-induced Experimental Pulmonary Hypertension.芳基烃受体在 Sugen 5416 诱导的实验性肺动脉高压中的作用。
Am J Respir Cell Mol Biol. 2018 Mar;58(3):320-330. doi: 10.1165/rcmb.2017-0260OC.
3
Pulmonary vascular and ventricular dysfunction in the susceptible patient (2015 Grover Conference series).易感患者的肺血管和心室功能障碍（2015年格罗弗会议系列）
Pulm Circ. 2016 Dec;6(4):426-438. doi: 10.1086/688315.
4
Anastrozole in Pulmonary Arterial Hypertension. A Randomized, Double-Blind, Placebo-controlled Trial.阿那曲唑治疗肺动脉高压：一项随机、双盲、安慰剂对照试验
Am J Respir Crit Care Med. 2017 Feb 1;195(3):360-368. doi: 10.1164/rccm.201605-1024OC.
5
17β-Estradiol mediates superior adaptation of right ventricular function to acute strenuous exercise in female rats with severe pulmonary hypertension.17β-雌二醇介导重度肺动脉高压雌性大鼠右心室功能对急性剧烈运动的更好适应。
Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L375-88. doi: 10.1152/ajplung.00132.2016. Epub 2016 Jun 10.
6
Altitude Adaptation: A Glimpse Through Various Lenses.高原适应：多视角一瞥
High Alt Med Biol. 2015 Jun;16(2):125-37. doi: 10.1089/ham.2015.0033.
7
Progress in solving the sex hormone paradox in pulmonary hypertension.肺动脉高压中性激素悖论的研究进展。
Am J Physiol Lung Cell Mol Physiol. 2014 Jul 1;307(1):L7-26. doi: 10.1152/ajplung.00337.2013. Epub 2014 May 9.
8
Regulation of hypoxia-induced pulmonary hypertension by vascular smooth muscle hypoxia-inducible factor-1α.血管平滑肌缺氧诱导因子-1α对低氧性肺动脉高压的调节作用。
Am J Respir Crit Care Med. 2014 Feb 1;189(3):314-24. doi: 10.1164/rccm.201302-0302OC.
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Drastic shift from positive to negative estrogen effect on bone morphogenetic protein signaling in pulmonary arterial endothelial cells under hypoxia.低氧条件下肺动脉内皮细胞中骨形态发生蛋白信号转导中雌激素作用从阳性急剧转变为阴性。
Circ J. 2013;77(8):2118-26. doi: 10.1253/circj.cj-12-0997. Epub 2013 May 18.
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17β-Estradiol attenuates hypoxic pulmonary hypertension via estrogen receptor-mediated effects.17β-雌二醇通过雌激素受体介导的作用减轻低氧性肺动脉高压。
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