School of Health Science, Hibernia College, Dublin, Ireland.
Centre for Research in Occupational Safety and Health, Laurentian University, Sudbury, Ontario, Canada; School of Rural and Northern Health, Laurentian University, Canada; Department of Occupational Therapy and Occupational Science, University of Toronto, Ontario, Canada.
Respir Med. 2018 Jul;140:82-86. doi: 10.1016/j.rmed.2018.06.004. Epub 2018 Jun 8.
Asthma is a common medical condition that impacts the lives of many Canadians; yet the health-related quality of life (HRQoL) in persons with asthma relative to the general population (GP) is poorly studied. In this study, data from the Canadian Community Health Survey (CCHS) 2013 was used to quantify and compare the HRQoL of the asthmatic population (AP) and the GP.
A representative survey sample of Canadians was taken from the CCHS to compare the Health Utilities Index Mark 3 (HUI3) scores, a generic HRQoL measure, between the AP (n = 572) and the GP (n = 6518). The HUI3 multi-attribute utility (MAU) and the single-attribute utility (SAU) scores between the two sample groups were studied. The CCHS 2013 dataset was explored as the primary analysis, while the 2012 dataset was used as the confirmatory analysis to verify the consistency of the results.
Clinically important difference was found in the MAU score between the AP and GP (p < 0.001, Effect size = 0.30). MANOVA on the eight SAU scores with post-hoc test revealed that the AP had a lower mean score of vision (p < 0.001, Effect size = 0.36) and pain/disconfort (p < 0.001, Effect size = 0.29). Those findings were consistent with the CCHS 2012 dataset result.
These results provided evidence that in Canada, having asthma significantly worsens asthma patients' overall HRQoL and imposes significant impacts on the patients' vision and pain/discomfort. Therefore, there is room for improvement in the currently available asthma therapies so patients could achieve better HRQoL; particular focus should be given to the pain/discomfort and vision health domains.
哮喘是一种常见的医学病症，影响着许多加拿大人的生活；然而，相对于普通人群（GP），哮喘患者的健康相关生活质量（HRQoL）研究甚少。在这项研究中，使用了 2013 年加拿大社区健康调查（CCHS）的数据，以量化和比较哮喘患者人群（AP）和 GP 的 HRQoL。
从 CCHS 中抽取了一个有代表性的加拿大人群样本，以比较哮喘患者人群（AP）和普通人群（GP）之间的健康效用指数 3 分（HUI3）得分，这是一种通用的 HRQoL 衡量标准。研究了两个样本组之间的 HUI3 多属性效用（MAU）和单一属性效用（SAU）得分。CCHS 2013 数据集被用作主要分析，而 2012 数据集被用作验证分析，以验证结果的一致性。
在 AP 和 GP 之间的 MAU 得分中发现了有临床意义的差异（p < 0.001，效应量= 0.30）。对八个 SAU 得分进行的 MANOVA 检验和事后检验显示，AP 的视力得分较低（p < 0.001，效应量= 0.36）和疼痛/不适得分较低（p < 0.001，效应量= 0.29）。这些发现与 CCHS 2012 数据集的结果一致。
这些结果提供了证据表明，在加拿大，患有哮喘显著降低了哮喘患者的整体 HRQoL，并对患者的视力和疼痛/不适产生了重大影响。因此，目前可用的哮喘治疗方法还有改进的空间，以便患者能够获得更好的 HRQoL；应特别关注疼痛/不适和视力健康领域。
