中东-北非地区 HLA-DRB1 多态性与多发性硬化易感性的系统评价和荟萃分析。
HLA-DRB1 polymorphism and susceptibility to multiple sclerosis in the Middle East North Africa region: A systematic review and meta-analysis.
机构信息
MS Research Centre, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran; Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran; Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
MS Research Centre, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran; Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
J Neuroimmunol. 2018 Aug 15;321:117-124. doi: 10.1016/j.jneuroim.2018.06.005. Epub 2018 Jun 6.
This meta-analysis explores association of HLA-DRB1 alleles with MS risk in the Middle-east North Africa (MENA) countries. Divided into two groups of alleles (10 studies, 899 cases/1457 controls) and phenotypes (8 studies, 1,040 cases/1,256 controls), Odds ratios (ORs) of DRB1 distribution in MS subjects were assessed using Cochrane RevMan software. DRB115 demonstrated significant association with MS in both groups (OR=1.6 and OR=2.51, respectively). In phenotypes, DRB103 and DRB104 had predisposing role (OR=1.8 and OR=1.9), while DRB107 and DRB1*11 were protective (OR=0.56 and OR=0.67). Similar but non-significant trends were seen among alleles, which in sum coincides with a Caucasian-like pattern.
这项荟萃分析探讨了 HLA-DRB1 等位基因与中东-北非（MENA）国家多发性硬化症（MS）风险的关联。将等位基因（10 项研究，899 例病例/1457 例对照）和表型（8 项研究，1040 例病例/1256 例对照）分为两组，使用 Cochrane RevMan 软件评估 MS 患者 DRB1 分布的优势比（OR）。在两组中，DRB115 均与 MS 显著相关（OR=1.6 和 OR=2.51）。在表型中，DRB103 和 DRB104 具有易感性作用（OR=1.8 和 OR=1.9），而 DRB107 和 DRB1*11 则具有保护作用（OR=0.56 和 OR=0.67）。等位基因中也存在类似但无统计学意义的趋势，总体上与白种人模式一致。
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