Department of Pharmacy, Summa Health, Akron, OH, United States.
School of Pharmacy, Cedarville University, 251 N. Main Street, Cedarville.45314, OH, United States.
J Affect Disord. 2018 Oct 1;238:645-650. doi: 10.1016/j.jad.2018.05.043. Epub 2018 Jun 26.
Bipolar Disorder (BD) presents in 1-4% of the world's population, carrying significant financial and functional consequences. Beyond the direct disease burden, patients with BD experience a high degree of both internal and external stigma. Additionally, medication adherence tends to be poor in patients with BD. Knowledge appears to play a role in mitigating both stigma and non-adherence, but these relationships have not been fully elucidated. The Bipolar Disorder Knowledge Scale (BDKS) was designed to explore the role of knowledge and better define such relationships. This research provides the evidence for the reliability and validity of the scale.
Forty-seven items were developed to assess knowledge of BD. The 47-item survey was sent out to two groups: first a group of 43 pharmacists with BCPP credentials from the College of Psychiatric and Neurologic Pharmacists (CPNP) who were recruited from the CPNP directory, and second a group of 250 members of the general public who were recruited using Qualtrics Online Sample service. Participants were surveyed on their education status, health literacy, BD diagnostic status, and exposure to patients with BD. Participants then completed the 47-item scale. After 48 h 100 members from the original general public group were sent the same survey to assess test-retest reliability. For each item a difficulty index to evaluate how well participants performed on the item and a discrimination index to determine how well each item performed in high-scorers versus low scorers were calculated. Additionally, Cronbach's alpha was calculated to determine internal consistency validity and a Pearson correlation was run to determine test-retest reliability. Items were removed based on the results from the difficulty index, discrimination index, and Cronbach's alpha. Finally the pharmacist final scores were compared to the general public using an unpaired t-test to assess whether content experts were more likely to perform better on the scale. Following item removal, the scale was finalized at 25-items.
The mean score for the scale was 34.48 (71.83%; SD: 5.50) and the Cronbach's alpha was 0.773 before item analysis. Following item analysis, 22 items were dropped leaving 25 items on the final version of the scale. The remaining items retained a difficulty index below 90% and a discrimination index above 20%. The mean of the 25-item scale was 18.40 (73.6%; SD: 4.13) for the general public and 23.20 (92.8%; SD: 1.36) for the pharmacists group (p < 0.001). The Cronbach's alpha for the finalized scale was 0.760, indicating a high-degree of internal consistency. While this is lower than the original alpha, this may be explained by the reduced number of scale items. A 25-item scale is much more practical and the items on the scale retain stronger item analysis statistics. Finally, the Pearson Correlation for the group who underwent the test-retest procedure was 0.841 (p < 0.001) indicating strong test-retest reliability.
The BDKS is a 25-item true-false scale that takes approximately 5-10 min to complete. The scale assesses knowledge of BD with items targeting diagnosis, etiology, disease course, symptoms, treatment, and life impact. The scale has shown strong internal consistency and test-retest reliability in a general population and will be useful for evaluating knowledge of BD as it relates to stigma, non-adherence, and other variables.
双相情感障碍(BD)在全球人口中占 1-4%,带来了巨大的经济和功能后果。除了直接的疾病负担,BD 患者还承受着高度的内在和外在污名。此外,BD 患者的药物依从性往往较差。知识似乎在减轻污名和不依从方面发挥了作用,但这些关系尚未得到充分阐明。双相情感障碍知识量表(BDKS)旨在探索知识的作用,并更好地定义这些关系。本研究为该量表的信度和效度提供了证据。
设计了 47 个项目来评估 BD 的知识。该 47 项调查分发给两组:一组是来自精神病学和神经病学药剂师学院(CPNP)的 43 名具有 BCPP 证书的药剂师,他们是从 CPNP 名录中招募的,另一组是 250 名普通公众,他们是通过 Qualtrics Online Sample 服务招募的。参与者接受了关于他们的教育状况、健康素养、BD 诊断状况以及接触 BD 患者的调查。参与者完成了 47 项量表。48 小时后,向最初的普通公众组中的 100 名成员发送了相同的调查,以评估测试重测信度。对于每个项目,都计算了一个难度指数来评估参与者在项目上的表现,以及一个区分指数来确定每个项目在高分者和低分者中的表现。此外,还计算了克朗巴赫系数来确定内部一致性有效性,并进行了皮尔逊相关来确定测试重测信度。根据难度指数、区分指数和克朗巴赫系数的结果,删除了项目。最后,使用独立样本 t 检验比较药剂师和普通公众的最终分数,以评估内容专家是否更有可能在量表上表现更好。在项目剔除后,量表最终确定为 25 项。
该量表的平均得分为 34.48(71.83%;SD:5.50),在项目分析前克朗巴赫系数为 0.773。在项目分析后,22 个项目被删除,留下 25 个项目在最终版本的量表上。其余项目保留了低于 90%的难度指数和高于 20%的区分指数。普通公众的 25 项量表平均得分为 18.40(73.6%;SD:4.13),药剂师组得分为 23.20(92.8%;SD:1.36)(p<0.001)。最终量表的克朗巴赫系数为 0.760,表明具有高度的内部一致性。虽然这低于原始的 alpha 值,但这可能是由于量表项目数量减少所致。一个 25 项的量表更实用,并且量表上的项目保留了更强的项目分析统计数据。最后,接受测试重测程序的组的皮尔逊相关系数为 0.841(p<0.001),表明具有很强的测试重测信度。
BDKS 是一个 25 项的真-假量表,大约需要 5-10 分钟完成。该量表评估 BD 的知识,目标是诊断、病因、疾病过程、症状、治疗和生活影响。该量表在普通人群中表现出较强的内部一致性和测试重测信度,将有助于评估与污名、不依从和其他变量相关的 BD 知识。