Jolicoeur F B, Rondeau D B, Barbeau A, Wayner M J
Department of Neurobiology, Clinical Research Institute of Montreal, Quebec.
Neurobehav Toxicol. 1979;1 Suppl 1:175-8.
The purpose of the present study was to design a standard battery of tests capable of quantitatively characterizing ataxia and concomitant neurological signs in the rat. In addition to a systematic analysis of the walking gait of animals, tests for activity, catalepsy, rigidity and various reflexive responses were included in the battery. The standardization of the test system was performed by determining and comparing neurobehavioral effects produced by 3-acetyl pyridine, acrylamide, pyrithiamine and thiamine deficiency, four experimental treatments reported to induce ataxia in animals. Results indicate that profiles of neurobehavioral disturbances accompanying ataxia in animals varied distinctively with each experimental treatment.
本研究的目的是设计一套标准测试组合，能够定量表征大鼠的共济失调及伴随的神经体征。除了对动物行走步态进行系统分析外，该测试组合还包括对活动、僵住症、僵硬及各种反射反应的测试。通过确定和比较3-乙酰吡啶、丙烯酰胺、硫胺素吡啶和硫胺素缺乏这四种据报道可在动物中诱发共济失调的实验处理所产生的神经行为效应，来实现测试系统的标准化。结果表明，动物共济失调伴随的神经行为障碍特征在每种实验处理下都有明显差异。
