Comparing bioimpedance spectrometry and traditional creatinine kinetics methods for the assessment of muscle mass in peritoneal dialysis patients.

BACKGROUND

Sarcopenia is a common and serious problem in patients receiving peritoneal dialysis (PD). Lean tissue mass (LTM) by bioimpedance spectrometry is a reasonably accurate method for measuring muscle mass. Fat-free edema-free body mass (FEBM) as determined by the creatinine kinetics method is a traditional method but evidence to support its use is limited.

METHODS

We studied 198 new PD patients. Their serial LTM and FEBM were reviewed and compared by the Bland and Altman method. Multi-variable regression model was used to determine factors associated with the disparity between the two methods.

RESULTS

There was a significant but moderate correlation between LTM and FEBM (r = 0.309,  < .0001). LTM was consistently higher than FEBM, with an average difference 13.98 kg (95% confidence interval -5.90 to 33.86 kg), and the difference strongly correlated with LTM (r = 0.781,  < .0001). By multivariable linear regression analysis, LTM and residual renal function were independent predictors of the LTM-FEBM difference. Where the measurements were repeated in 12 months, there was no significant correlation between ∆LTM and ∆FEBM (r = -0.031,  = .799).

CONCLUSION

There is a significant difference between LTM and FFBM. This discrepancy correlated with LTM and residual renal function, highlighting the limitations of FFBM in assessing skeletal muscle mass.