Arcanjo Francisco Plácido Nogueira, da Costa Rocha Thaís Cristina, Arcanjo Caio Plácido Costa, Santos Paulo Roberto
Department of Master's Degree in Family Health, Federal University of Ceará , Sobral , Brazil.
Department of Medicine, University of Fortaleza , Fortaleza , Brazil.
J Diet Suppl. 2019;16(6):689-698. doi: 10.1080/19390211.2018.1474987. Epub 2018 Jun 29.
The aim of this study was to evaluate the effectiveness of NutriSUS micronutrient fortification, in infants aged 12-36 months, for the prophylaxis and treatment of iron deficiency anemia. In this cluster-randomized clinical trial study, we evaluated infants aged 12-36 months. Length of intervention was 12 weeks. Children were cluster randomized to either NutriSUS micronutrient fortification (Group A) or control (Group B). Primary outcome variables were change in hemoglobin concentration and anemia prevalence. Two biochemical evaluations were performed to determine hemoglobin concentrations: before and after intervention. This study was conducted in eight child-care centers located within the urban perimeter of the municipality of Sobral, Ceará, in the northeast of Brazil. For Group A, baseline mean hemoglobin concentration was 11.4 ± 1.01 g/dL; after intervention it was 11.9 ± 0.90 g/dL ( = .006); 15 of 20 participants who were anemic at baseline had normal Hb levels after intervention. Number needed to treat = 2. In group B, mean baseline hemoglobin was 11.9 ± 0.89 g/dL; after intervention it was 12.2 ± 0.92 g/dL ( = .58); 4 of 5 participants who were anemic at baseline remained anemic after intervention. In our study, NutriSUS micronutrient fortification provided a beneficial effect on Hb values, reducing the prevalence of anemia. However, further studies are necessary to confirm the effectiveness of this intervention in populations on a larger scale.
本研究的目的是评估NutriSUS微量营养素强化对12至36个月大婴儿缺铁性贫血的预防和治疗效果。在这项整群随机临床试验研究中，我们评估了12至36个月大的婴儿。干预时长为12周。儿童被整群随机分为NutriSUS微量营养素强化组（A组）或对照组（B组）。主要结局变量为血红蛋白浓度变化和贫血患病率。进行了两次生化评估以确定血红蛋白浓度：干预前和干预后。本研究在巴西东北部塞阿拉州索布拉尔市城市周边的八个儿童保育中心进行。对于A组，基线平均血红蛋白浓度为11.4±1.01 g/dL；干预后为11.9±0.90 g/dL（P = 0.006）；基线时贫血的20名参与者中有15名在干预后血红蛋白水平正常。治疗所需人数=2。在B组中，基线平均血红蛋白为11.9±0.89 g/dL；干预后为12.2±0.92 g/dL（P = 0.58）；基线时贫血的5名参与者中有4名在干预后仍贫血。在我们的研究中，NutriSUS微量营养素强化对血红蛋白值产生了有益影响，降低了贫血患病率。然而，需要进一步研究以在更大规模人群中证实这种干预措施的有效性。
