Kishibuchi Reina, Nishibori Naoyoshi, Sagara Takefumi, Morita Kyoji
Life Science Research Group, Shikoku University School of Health Sciences , Tokushima , Japan.
Department of Food Science and Nutrition, Shikoku Junior College , Tokushima , Japan.
J Diet Suppl. 2019;16(5):521-529. doi: 10.1080/19390211.2018.1472166. Epub 2018 Jun 29.
Excessive calorie intake is generally accepted as a primary cause of metabolic syndrome, and therefore a well-balanced diet and moderate exercise can be expected to be the most effective measures to avoid the disorder of energy utilization and storage. Furthermore, as any other way to improve the disorder of energy balance, it may be effective to delay and lower the digestion and/or absorption of energy sources, lipids, and carbohydrates. As a primary screening of effective substances to delay and lower the digestion and absorption processes among natural materials, the protein-deprived extract was prepared from blue-green algae , and the effect of this extract on lipase and α-glucosidase activities was examined. The extract was shown to inhibit lipase activity but not α-glucosidase activity, thus proposing the possibility that the extract prevented the postprandial elevation of blood triglyceride (TG) levels as a result of reducing the digestion and absorption of lipids in the intestinal tract. Therefore, it seems possible to speculate that nonprotein components of may be able to effectively improve the disorder of energy balance as a consequence of suppressing the excessive intake of calories by reducing the absorption of lipids in patients with metabolic syndrome.
热量摄入过多通常被认为是代谢综合征的主要原因，因此，均衡饮食和适度运动有望成为避免能量利用和储存紊乱的最有效措施。此外，作为改善能量平衡紊乱的任何其他方法，延迟和降低能量来源、脂质和碳水化合物的消化和/或吸收可能是有效的。作为从天然材料中筛选延迟和降低消化吸收过程的有效物质的初步研究，从蓝藻中制备了蛋白质缺乏提取物，并检测了该提取物对脂肪酶和α-葡萄糖苷酶活性的影响。结果表明，该提取物可抑制脂肪酶活性，但不抑制α-葡萄糖苷酶活性，因此提示该提取物可能通过减少肠道脂质的消化和吸收来预防餐后血甘油三酯（TG）水平升高。因此，似乎可以推测，蓝藻的非蛋白质成分可能通过抑制代谢综合征患者的脂质吸收来抑制热量的过度摄入，从而有效改善能量平衡紊乱。
