Babitha S, Bindu K, Nageena Taj, Veerapur V P
a Department of Pharmacology , Sree Siddaganga College of Pharmacy , Tumkur , Karnataka , India.
b Department of Quality Assurance , Sree Siddaganga College of Pharmacy , Tumkur , Karnataka , India.
J Diet Suppl. 2019;16(4):431-442. doi: 10.1080/19390211.2018.1470128. Epub 2018 Jun 29.
The present study aimed to evaluate the protective effect of fresh fruit juice of Haw. (FJOD) on acetic acid-induced ulcerative colitis in rats. Fresh FJOD (2.5 and 5 ml/kg) and sulfasalazine (100 mg/kg) were given orally for seven consecutive days prior to colitis induction on the eighth day by intrarectal acetic acid (4% v/v) administration. Macroscopic, clinical activity scoring, biochemical, and histopathological examinations of colon were used to assess colonic damage. FJOD and sulfasalazine treatment significantly attenuated the macroscopic damage, clinical activity score, and wet weight of the colon when compared to disease control and further showed significantly reduced levels of myeloperoxidase, malondialdehyde, and serum lactate dehydrogenase and enhanced colonic levels of reduced glutathione. The protective effect of FJOD may be attributed to its antioxidant and anti-inflammatory activities in ulcerative colitis. The observed effects may be due to the presence of phenolics, flavonoids, and betalains in the fruit juice of .
本研究旨在评估山楂鲜果汁（FJOD）对大鼠乙酸诱导的溃疡性结肠炎的保护作用。在第八天通过直肠内给予4%（v/v）乙酸诱导结肠炎之前，连续七天口服新鲜FJOD（2.5和5毫升/千克）和柳氮磺胺吡啶（100毫克/千克）。采用结肠的宏观、临床活动评分、生化和组织病理学检查来评估结肠损伤。与疾病对照组相比，FJOD和柳氮磺胺吡啶治疗显著减轻了宏观损伤、临床活动评分和结肠湿重，并进一步显示髓过氧化物酶、丙二醛和血清乳酸脱氢酶水平显著降低，结肠中还原型谷胱甘肽水平升高。FJOD的保护作用可能归因于其在溃疡性结肠炎中的抗氧化和抗炎活性。观察到的效果可能是由于山楂果汁中存在酚类、黄酮类和甜菜碱。
