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基于树状高分子-聚合物缀合物自组装的药物传递系统。

Drug Delivery Systems from Self-Assembly of Dendron-Polymer Conjugates .

机构信息

Department of Chemistry, Bogazici University, Bebek, 34342 Istanbul, Turkey.

Center for Life Sciences and Technologies, Bogazici University, 34342 Istanbul, Turkey.

出版信息

Molecules. 2018 Jun 28;23(7):1570. doi: 10.3390/molecules23071570.

Abstract

This review highlights the utilization of dendron-polymer conjugates as building blocks for the fabrication of nanosized drug delivery vehicles. The examples given provide an overview of the evolution of these delivery platforms, from simple micellar containers to smart stimuli- responsive drug delivery systems through their design at the macromolecular level. Variations in chemical composition and connectivity of the dendritic and polymeric segments provide a variety of self-assembled micellar nanostructures that embody desirable attributes of viable drug delivery systems.

摘要

这篇综述强调了树状聚合物缀合物作为构建纳米药物传递载体的应用。所举的例子概述了这些递药平台的演变,从简单的胶束容器到通过在大分子水平上设计的智能刺激响应药物传递系统。树枝状和聚合物段的化学组成和连接性的变化提供了多种自组装胶束纳米结构,体现了可行的药物传递系统的理想属性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e972/6099537/66ae0497695f/molecules-23-01570-sch001.jpg

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