一个被重新审视的概念。肿瘤：无法愈合的创伤。

A revisited concept. Tumors: Wounds that do not heal.

机构信息

Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, National Cancer Institute "Giovanni Paolo II", Bari, Italy.

出版信息

Crit Rev Oncol Hematol. 2018 Aug;128:65-69. doi: 10.1016/j.critrevonc.2018.05.016. Epub 2018 Jun 6.

DOI:10.1016/j.critrevonc.2018.05.016

PMID:29958632

Abstract

In 1986, Harold F. Dvorak, Professor of Pathology at Harvard Medical School Boston, published an essay in the New England Journal of Medicine entitled "Tumors: Wounds that do not heal" pointed out that similarities exist between tumor stroma generation and wound healing. Cancers share many features in common with tissue regeneration, including immune response, cell proliferation, cell migration, tissue remodeling, and cell death. In this review article, we analyze the importance and the limits of this concept, which confirm the close relationship between two apparently different biological processes.

摘要

1986 年，波士顿哈佛医学院病理学教授哈罗德·F·德沃拉克（Harold F. Dvorak）在《新英格兰医学杂志》上发表了一篇题为《肿瘤：无法愈合的创伤》的文章，指出肿瘤基质生成与伤口愈合之间存在相似之处。癌症与组织再生有许多共同特征，包括免疫反应、细胞增殖、细胞迁移、组织重塑和细胞死亡。在这篇综述文章中，我们分析了这一概念的重要性和局限性，这证实了两个明显不同的生物学过程之间的密切关系。