Ophthalmic Research Group, Life and Health Sciences, Aston University, Birmingham UK; Department of Ophthalmology, New Zealand National Eye Centre, The University of Auckland, Auckland, New Zealand.
Ophthalmic Research Group, Life and Health Sciences, Aston University, Birmingham UK; Department of Ophthalmology, New Zealand National Eye Centre, The University of Auckland, Auckland, New Zealand.
Cont Lens Anterior Eye. 2018 Oct;41(5):421-425. doi: 10.1016/j.clae.2018.06.003. Epub 2018 Jun 27.
To evaluate the patient-administered Optrex Dry Eye Blink Test against established clinical criteria for the diagnosis of dry eye disease (DED) and to evaluate its benefit in enhancing screening for DED.
Eighty-seven participants aged 38 ± 17 years, (44 female) were screened for DED using the Tear Film and Ocular Surface Society Dry Eye Workshop II (TFOS DEWS II) diagnostic criteria. In addition to symptoms screening with the Ocular Surface Disease Index questionnaire (≥13 cut-off score for DED), these criteria required a sign of loss of homeostasis of the tear film in the form of a non-invasive tear breakup time (NIBUT) <10 s (Oculus Keratograph; K5M), an osmolarity reading ≥308 mOsm/L or an interocular difference in osmolarity of >8 (Tearlab), or ocular surface staining (>5 fluorescein corneal spots, >9 lissamine green spots or lid wiper staining [≥2 mm length & ≥25% width]) to confirm a diagnosis of DED. The self-administered Blink Test, which requires the participant to observe an image on a computer screen and report the length of time (in seconds) that they can refrain from blinking without discomfort, was repeated three times.
Using a cut-off time of 10 s, the Blink Test demonstrated sensitivity of 66%, specificity of 88%, and an area under the curve of 0.77 (p < 0.001), in predicting a diagnosis of DED according to the TFOS DEWS II criteria. The correlation between the Blink Test and NIBUT was r = 0.47 (p < 0.001). When combined with the screening questionnaire, the sensitivity and specificity of the Blink Test increased to 71% and 90%, respectively.
The Blink Test offers health professionals without advanced instrumentation, as well as patients, themselves, a rapid method of identifying possible DED.
评估患者自主进行的 Optrex 干眼眨眼测试在诊断干眼疾病（DED）方面与既定临床标准的相关性，并评估其在增强 DED 筛查方面的益处。
对 87 名年龄 38±17 岁（女性 44 名）的参与者进行 DED 筛查，使用泪膜和眼表面协会干眼工作 II 期（TFOS DEWS II）诊断标准。除了使用眼表面疾病指数问卷进行症状筛查（DED 的临界值≥13 分），这些标准还需要泪膜稳态丧失的迹象，形式为非侵入性泪膜破裂时间（NIBUT）<10 秒（Oculus Keratograph；K5M）、渗透压读数≥308 mOsm/L 或眼间渗透压差异>8（Tearlab），或眼表面染色（>5 个角膜荧光素点、>9 个丽丝胺绿点或眼睑擦拭染色[≥2mm 长度和≥25%宽度]）以确认 DED 的诊断。自我管理的眨眼测试要求参与者观察计算机屏幕上的图像，并报告他们在不感到不适的情况下可以眨眼的时间（以秒为单位），该测试重复进行了 3 次。
使用 10 秒的截断时间，眨眼测试在根据 TFOS DEWS II 标准预测 DED 诊断时，显示出 66%的敏感性、88%的特异性和 0.77 的曲线下面积（p<0.001）。眨眼测试与 NIBUT 之间的相关性为 r=0.47（p<0.001）。当与筛查问卷结合使用时，眨眼测试的敏感性和特异性分别提高到 71%和 90%。
眨眼测试为没有先进仪器的医疗保健专业人员以及患者自身提供了一种快速识别可能的 DED 的方法。
