Iovino M, Steardo L
Eur J Pharmacol. 1985 Jul 11;113(1):99-103. doi: 10.1016/0014-2999(85)90347-4.
Studies were carried out in the rat to investigate whether serotonin (5-HT) is involved in the regulation of vasopressin (ADH) release. For this purpose plasma ADH levels were measured in rats treated with drugs enhancing 5-HT transmission, such as d-fenfluramine and quipazine and with 5-HT depleting drugs, p-chlorophenylalanine (PCPA) and 5,7-dihydroxytryptamine (5,7-DHT). Forebrain 5HT, noradrenaline (NA) and dopamine (DA) were also measured. d-Fenfluramine and quipazine induced dose-related increases in plasma ADH levels in normohydrated rats. The effects of quipazine and d-fenfluramine were prevented by PCPA, indicating that 5-HT transmission was required for the biologic response. 5,7-DHT and PCPA pretreatment decreased forebrain 5-HT content and prevented ADH increases involved by water deprivation, suggesting that 5HT is necessary for the hormonal response to osmotic stimuli. The results summarized imply that serotonin may have a role in the physiological release of ADH from neurohypophysis.
在大鼠中开展了多项研究，以调查血清素（5-羟色胺，5-HT）是否参与抗利尿激素（ADH）释放的调节。为此，在使用增强5-HT传递的药物（如右旋芬氟拉明和喹哌嗪）以及5-HT耗竭药物（对氯苯丙氨酸，PCPA和5,7-二羟色胺，5,7-DHT）处理的大鼠中测量血浆ADH水平。还测量了前脑5-羟色胺、去甲肾上腺素（NA）和多巴胺（DA）。右旋芬氟拉明和喹哌嗪在正常水合的大鼠中诱导血浆ADH水平呈剂量相关的升高。PCPA可阻止喹哌嗪和右旋芬氟拉明的作用，表明生物反应需要5-HT传递。5,7-DHT和PCPA预处理降低了前脑5-羟色胺含量，并阻止了因缺水引起的ADH升高，这表明5-羟色胺对于激素对渗透压刺激的反应是必需的。总结的结果表明，血清素可能在神经垂体ADH的生理释放中起作用。
