Preptin 是冠状动脉钙化的新预测因子。

Preptin is a new predictor of coronary artery calcification.

机构信息

Department of Cardiology, Central Hospital of Zibo, NO, 54, Gong Qing Tuan Xi Road, Zibo 255036, PR China.

Department of Imaging, Central Hospital of Zibo, NO, 54, Gong Qing Tuan Xi Road, Zibo 255036, PR China.

出版信息

Clin Chim Acta. 2018 Oct;485:133-138. doi: 10.1016/j.cca.2018.06.038. Epub 2018 Jun 26.

DOI:10.1016/j.cca.2018.06.038

PMID:29958889

Abstract

BACKGROUND

We aimed to assess whether an elevated preptin level is associated with coronary artery calcification (CAC).

METHODS

Two hundred and twenty participants with suspected cardiovascular disease were recruited. CAC was measured using 320-row-detector dynamic volume CT, and the patients were divided into 2 groups: the non-CAC group (with an Agatston score = 0) and the CAC group (with an Agatston score > 0).

RESULTS

The serum preptin level was significantly elevated in the CAC group compared with the non-CAC group. In logistic regression analysis, preptin, as well as age, gender, hypertension history and history of β-blocker use, were independent predictors of a positive CAC score. The highest preptin quintile of patients had a higher CAC level compared with other quintiles. Binary logistic regression analyses showed that the highest preptin quintile had a 2.9-time increased odds ratio of an elevated CAC level than the other 4 quintile patients.

CONCLUSIONS

This study demonstrated that serum preptin was associated with coronary artery calcification.

摘要

背景

本研究旨在评估血清前胃泌素原水平升高与冠状动脉钙化（CAC）之间的相关性。

方法

共纳入 220 例疑似心血管疾病患者。采用 320 排动态容积 CT 测量 CAC，将患者分为 CAC 组（Agatston 评分>0）和非 CAC 组（Agatston 评分=0）。

结果

与非 CAC 组相比，CAC 组患者的血清前胃泌素原水平显著升高。多因素 logistic 回归分析显示，前胃泌素原以及年龄、性别、高血压病史和β受体阻滞剂使用史是 CAC 评分阳性的独立预测因素。前胃泌素原最高五分位数的患者 CAC 水平明显高于其他五分位数。二元 logistic 回归分析显示，与其他四分位数患者相比，前胃泌素原最高五分位数患者的 CAC 水平升高的优势比为 2.9 倍。