Benoist P, Mureau A, Joueidi Y, Arbion F, Vilde A, Body G, Michenet P, Leveque J, Ouldamer L
Department of Gynecology, Centre Hospitalier Régional Universitaire de Tours, Hôpital Bretonneau, 2 boulevard Tonnellé, 37044 Tours, France; François-Rabelais University, Tours, France.
François-Rabelais University, Tours, France; Department of Radiology, Centre Hospitalier Régional Universitaire de Tours, Hôpital Bretonneau, 2, boulevard Tonnellé, 37044 Tours, France.
J Gynecol Obstet Hum Reprod. 2018 Sep;47(7):275-280. doi: 10.1016/j.jogoh.2018.06.007. Epub 2018 Jun 27.
The aim of the study was to investigate the management and prognosis of Pure primary squamous cell carcinoma (PPSCC) of the breast.
This study is a multicentre retrospective cohort from three French tertiary referral hospitals (Rennes, Orléans and Tours) including all women treated for a PPSCC of the breast defined by squamous cells that could contain a minority of sarcomatoid component. We excluded carcinomas with a ductual component. Clinicopathologic, radiological and therapeutic patterns were described. Demographic, histological and therapeutic characteristics were compared to a population of women with triple negative invasive breast carcinomas.
Twelve patients were included, with a mean age of 71.6 years. All lesions were unifocal, with a cystic complex ultrasound mass in 50% of cases. Mean tumor size was 43mm, with axillary lymph node metastasis in 25% of patients. The comparison with a population of women with triple negative breast carcinomas revealed that women with PPSCC were older (71 versus 57 years, p=0.003), tumor size was larger (43mm versus 25mm, p=0.032) and local recurrence occurred earlier (three months versus 38 months, p=0.014).
PPSCC is a rare entity with a worse prognosis in comparison with triple negative invasive carcinoma.
本研究旨在调查乳腺纯原发性鳞状细胞癌（PPSCC）的管理和预后。
本研究是一项来自法国三家三级转诊医院（雷恩、奥尔良和图尔）的多中心回顾性队列研究，纳入了所有接受治疗的乳腺PPSCC女性患者，其定义为鳞状细胞癌，可能包含少数肉瘤样成分。我们排除了具有导管成分的癌。描述了临床病理、放射学和治疗模式。将人口统计学、组织学和治疗特征与三阴性浸润性乳腺癌女性人群进行了比较。
纳入12例患者，平均年龄71.6岁。所有病变均为单灶性，50%的病例超声显示为囊实性肿块。平均肿瘤大小为43mm，25%的患者有腋窝淋巴结转移。与三阴性乳腺癌女性人群的比较显示，PPSCC女性患者年龄更大（71岁对57岁，p = 0.003），肿瘤更大（43mm对25mm，p = 0.032），局部复发更早（3个月对38个月，p = 0.014）。
与三阴性浸润性癌相比，PPSCC是一种罕见的实体，预后较差。
