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A non-myeloablative conditioning approach for long-term engraftment of human and mouse hematopoietic stem cells.

作者信息

Du Wei, Liu Wei, Mizukawa Benjamin, Shang Xun, Sipple Jared, Wunderlich Mark, Geiger Hartmut, Davies Stella, Mulloy James, Pang Qishen, Zheng Yi

机构信息

Cancer and Blood Diseases Institute, Molecular and Developmental Biology Graduate Program, Children's Hospital Research Foundation, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.

Department of Pharmaceutical Sciences, West Virginia University School of Pharmacy, 1 Medical Center Dr., Morgantown, WV, 26506, USA.

出版信息

Leukemia. 2018 Sep;32(9):2041-2046. doi: 10.1038/s41375-018-0200-3. Epub 2018 Jun 29.

DOI:10.1038/s41375-018-0200-3
PMID:29959415
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6128741/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/281c/6128741/918158220585/nihms-980704-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/281c/6128741/07133f2163b4/nihms-980704-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/281c/6128741/918158220585/nihms-980704-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/281c/6128741/07133f2163b4/nihms-980704-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/281c/6128741/918158220585/nihms-980704-f0002.jpg

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Rational identification of a Cdc42 inhibitor presents a new regimen for long-term hematopoietic stem cell mobilization.合理鉴定 Cdc42 抑制剂为长期造血干细胞动员提出了新方案。
Leukemia. 2019 Mar;33(3):749-761. doi: 10.1038/s41375-018-0251-5. Epub 2018 Sep 25.
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Bone Marrow Transplant. 2018 Jan;53(1):108-110. doi: 10.1038/bmt.2017.224. Epub 2017 Oct 23.
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KIT blockade is sufficient for donor hematopoietic stem cell engraftment in Fanconi anemia mice.在范可尼贫血小鼠中,抑制KIT足以使供体造血干细胞植入。
Blood. 2017 Feb 23;129(8):1048-1052. doi: 10.1182/blood-2015-12-689083. Epub 2016 Dec 20.
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Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment.分离能够长期多谱系植入的单个人类造血干细胞。
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Leukemia. 2011 Aug;25(8):1286-1296. doi: 10.1038/leu.2011.62. Epub 2011 Apr 15.
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Blood. 2010 Dec 9;116(24):5419-22. doi: 10.1182/blood-2010-07-295949. Epub 2010 Sep 2.
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Biol Blood Marrow Transplant. 2008 Sep;14(9):1045-1056. doi: 10.1016/j.bbmt.2008.07.004.