双黄酮贝壳杉黄酮的体外抗氧化特性
In vitro antioxidant properties of the biflavonoid agathisflavone.
作者信息
Andrade Anderson Wilbur Lopes, Machado Keylla da Conceição, Machado Katia da Conceição, Figueiredo Daiana Dias Ribeiro, David Jorge Mauricio, Islam Muhammad Torequl, Uddin Shaikh Jamal, Shilpi Jamil A, Costa Jéssica Pereira
机构信息
Laboratory of Research in Experimental Neurochemistry, Federal University of Piauí (UFPI), Teresina, Brazil.
Chemistry Institute, Federal University of Bahia (UFBA), Salvador, Brazil.
出版信息
Chem Cent J. 2018 Jun 29;12(1):75. doi: 10.1186/s13065-018-0443-0.
PURPOSE
Free radicals are considered as the causative agents of a variety of acute and chronic pathologies. Natural antioxidants have drawn attention of the researchers in recent years for their ability to scavenge free radicals with minimal or even no side effects. This study evaluates the antioxidant capacity of agathisflavone, a naturally occurring biflavonoid by a number of in vitro methods.
METHODS
Agathisflavone was subjected to DPPH, ABTS, OH and NO radical scavenging assay, reducing potential and inhibition of lipid peroxidation (TBARS) test using trolox as a standard.
RESULTS
Agathisflavone showed concentration-dependent antioxidant activity against all types of free radicals used in this study. The antioxidant capacity, reducing potential and inhibition of lipid peroxidation showed by agathisflavone were comparable to that of trolox.
CONCLUSION
Agathisflavone exhibited antioxidant capacity, which suggests considering this biflavonoid for the use in the prevention and/or treatment of diseases precipitated by oxidative stress.
目的
自由基被认为是多种急慢性疾病的致病因素。近年来，天然抗氧化剂因其能够清除自由基且副作用极小甚至无副作用而受到研究人员的关注。本研究通过多种体外方法评估了天然存在的双黄酮阿盖黄酮的抗氧化能力。
方法
以Trolox为标准，对阿盖黄酮进行DPPH、ABTS、OH和NO自由基清除试验、还原电位和脂质过氧化抑制（TBARS）试验。
结果
阿盖黄酮对本研究中使用的所有类型自由基均表现出浓度依赖性抗氧化活性。阿盖黄酮表现出的抗氧化能力、还原电位和脂质过氧化抑制作用与Trolox相当。
结论
阿盖黄酮具有抗氧化能力，这表明可考虑将这种双黄酮用于预防和/或治疗由氧化应激引发的疾病。
Zotero 插件