肾上腺素能对糖异生的调节：α1肾上腺素能作用中两种信号转导机制的可能参与。
Adrenergic regulation of gluconeogenesis: possible involvement of two mechanisms of signal transduction in alpha 1-adrenergic action.
作者信息
García-Sáinz J A, Hernández-Sotomayor S M
出版信息
Proc Natl Acad Sci U S A. 1985 Oct;82(20):6727-30. doi: 10.1073/pnas.82.20.6727.
Abstract
We have previously suggested that the effects of alpha 1-adrenergic agents on hepatocyte metabolism involve two mechanisms: (i) a calcium-independent insulin-sensitive process that is modulated by glucocorticoids and (ii) a calcium-dependent insulin-insensitive process that is modulated by thyroid hormones. We have studied the effect of epinephrine (plus propranolol) on gluconeogenesis from lactate and dihydroxyacetone. It was observed that the adrenergic stimulation of gluconeogenesis from lactate seemed to occur through both mechanisms, whereas when the substrate was dihydroxyacetone the action took place exclusively through the calcium-independent insulin-sensitive process. This effect was absent in hepatocytes from adrenalectomized rats, suggesting that it is modulated by glucocorticoids.
摘要
我们之前曾提出，α1-肾上腺素能药物对肝细胞代谢的影响涉及两种机制：（i）一种不依赖钙的胰岛素敏感过程，受糖皮质激素调节；（ii）一种依赖钙的胰岛素不敏感过程，受甲状腺激素调节。我们研究了肾上腺素（加普萘洛尔）对乳酸和二羟丙酮糖异生的影响。观察到肾上腺素对乳酸糖异生的刺激似乎通过两种机制发生，而当底物是二羟丙酮时，作用仅通过不依赖钙的胰岛素敏感过程发生。这种作用在肾上腺切除大鼠的肝细胞中不存在，表明它受糖皮质激素调节。
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Adrenergic regulation of gluconeogenesis: possible involvement of two mechanisms of signal transduction in alpha 1-adrenergic action.肾上腺素能对糖异生的调节：α1肾上腺素能作用中两种信号转导机制的可能参与。
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