Moran Jean M, Molineu Andrea, Kruse Jon J, Oldham Mark, Jeraj Robert, Galvin James M, Palta Jatinder R, Olch Arthur J
University of Michigan, Ann Arbor, MI, USA.
University of Texas MD Anderson Cancer Center, Houston, TX, USA.
J Appl Clin Med Phys. 2018 Sep;19(5):335-346. doi: 10.1002/acm2.12384. Epub 2018 Jun 29.
The charge of AAPM Task Group 113 is to provide guidance for the physics aspects of clinical trials to minimize variability in planning and dose delivery for external beam trials involving photons and electrons. Several studies have demonstrated the importance of protocol compliance on patient outcome. Minimizing variability for treatments at different centers improves the quality and efficiency of clinical trials. Attention is focused on areas where variability can be minimized through standardization of protocols and processes through all aspects of clinical trials. Recommendations are presented for clinical trial designers, physicists supporting clinical trials at their individual clinics, quality assurance centers, and manufacturers.
美国医学物理学家协会（AAPM）第113任务组的职责是为临床试验的物理方面提供指导，以尽量减少涉及光子和电子的外照射试验在计划制定和剂量输送方面的变异性。多项研究已证明方案依从性对患者治疗结果的重要性。最大限度地减少不同中心治疗的变异性可提高临床试验的质量和效率。重点关注可通过临床试验各方面的方案和流程标准化来尽量减少变异性的领域。文中针对临床试验设计者、各诊所支持临床试验的物理学家、质量保证中心以及制造商提出了相关建议。
