Department of Cardiovascular Surgery, Gangnam Severance Hospital, Seoul, Republic of Korea.
Department of Cardiovascular Surgery, Gangnam Severance Hospital, Seoul, Republic of Korea.
Ann Thorac Surg. 2018 Oct;106(4):1079-1086. doi: 10.1016/j.athoracsur.2018.05.067. Epub 2018 Jun 28.
Tear-oriented surgical procedure is considered a standard treatment for acute DeBakey type I aortic dissection (AIAD). However, long-term surgical outcomes, including aortic growth and rate of major adverse aortic events (MAAEs), have yet to be clarified.
Of the 274 patients who underwent surgical repair for AIAD between 2009 and 2016, 105 patients with both predischarge and follow-up computed tomographic scans were enrolled. The surgical extent was determined by primary entry tear location. We measured aortic diameters (pulmonary artery bifurcation, maximum diameter of the descending thoracic aorta [maxDTA], and celiac axis) and compared MAAEs (aorta growth rate ≥ 5 mm/year or maxDTA ≥ 55 mm according to surgical extent).
Twenty-nine patients underwent total arch replacement (TAR); 76 underwent non-TAR. In the non-TAR group, patients with or without residual tears in the arch vessels were classified as having complete arch repair (non-TAR-CAR, n = 52) or incomplete arch repair (non-TAR-IAR, n = 24). Considerable differences were found in the aortic growth rate between the TAR and non-TAR groups and the non-TAR-CAR and non-TAR-IAR groups. Freedom from MAAEs at 5 years was considerably higher in the non-TAR-CAR group than in the non-TAR-IAR group (84.5% versus 31.1%). However, no differences were observed in the aortic growth rate and freedom from MAAEs between the TAR and non-TAR-CAR groups.
Classic tear-oriented surgical procedure is insufficient for optimal long-term surgical outcomes, mainly regarding aortic dilation. CAR without residual arch vessel tears leads to favorable aortic remodeling in the residual DTA and prevents MAAEs after AIAD repair.
对于急性 DeBakey Ⅰ型主动脉夹层(AIAD),以撕裂为导向的手术治疗被认为是一种标准治疗方法。然而,长期的手术结果,包括主动脉生长和主要不良主动脉事件(MAAE)的发生率,仍未得到明确。
在 2009 年至 2016 年间接受 AIAD 手术修复的 274 例患者中,有 105 例患者在出院前和随访时均进行了计算机断层扫描检查。手术范围由原发入口撕裂位置决定。我们测量了主动脉直径(肺动脉分叉处、降主动脉最大直径[maxDTA]和腹腔干动脉),并比较了 MAAE(根据手术范围,主动脉生长率≥5mm/年或 maxDTA≥55mm)。
29 例行全主动脉弓置换术(TAR);76 例行非 TAR。在非 TAR 组中,根据弓部血管是否存在残余撕裂,将患者分为完全弓部修复(非 TAR-CAR,n=52)或不完全弓部修复(非 TAR-IAR,n=24)。TAR 组与非 TAR 组之间,非 TAR-CAR 组与非 TAR-IAR 组之间的主动脉生长率差异较大。非 TAR-CAR 组的 MAAE 无事件生存率明显高于非 TAR-IAR 组(84.5%比 31.1%)。然而,TAR 组与非 TAR-CAR 组之间的主动脉生长率和 MAAE 无事件生存率无差异。
以撕裂为导向的经典手术方法不能达到最佳的长期手术效果,主要与主动脉扩张有关。无残余弓部血管撕裂的 CAR 可导致残余 DTA 的主动脉重塑,并预防 AIAD 修复后的 MAAE。