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杂交技术在急性 DeBakey I 型主动脉夹层中治疗 II 型弓部病变与全主动脉弓置换加冰冻象鼻技术的早期结果比较:倾向评分匹配分析。

Early outcomes of hybrid type II arch repair versus total arch replacement with frozen elephant trunk in acute DeBakey type I aortic dissection: a propensity score-matched analysis.

机构信息

State Key Laboratory of Cardiovascular Disease, Vascular Surgery Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

出版信息

Interact Cardiovasc Thorac Surg. 2020 Oct 1;31(4):565-572. doi: 10.1093/icvts/ivaa121.

Abstract

OBJECTIVES

The aim was to evaluate the short-term outcomes of hybrid type II arch repair (HAR) and total arch replacement with frozen elephant trunk (TAR with FET) for acute DeBakey type I aortic dissection patients.

METHODS

From January 2017 to June 2019, the clinical data of acute DeBakey type I aortic dissection patients in a single centre were retrospectively reviewed; there were 92 cases of HAR and 268 cases of TAR with FET, with 56 pairs by propensity score matching.

RESULTS

After matching, the composite end points including 30-day mortality, stroke, paraplegia, renal failure, hepatic failure, reintubation or tracheotomy and low cardiac output syndrome were comparable (21.4%, 12/56 in the HAR group vs 21.4%, 12/56 in the TAR with FET group, P = 1.000). The rate of acute kidney injury (AKI) was significantly lower in the HAR group (58.9%, 33/56 vs 80.4%, 45/56, P = 0.031). The distribution of AKI stage according to the Kidney Disease Improving Global Outcomes criteria was different (P = 0.039), with more patients suffering from high-grade AKI in the TAR with FET group. Multivariable logistic analysis showed that the procedure type (HAR or TAR with FET) was not an independent predictor of composite adverse events or stroke. HAR was identified as a protective factor against AKI (odds ratio 0.485, 95% confidence interval 0.287-0.822; P = 0.007).

CONCLUSIONS

In the treatment of acute DeBakey type I aortic dissection, no significant differences were found in early outcomes between the 2 groups, but HAR was associated with a significantly lower incidence of AKI.

摘要

目的

评估杂交型 II 弓部修复术(HAR)和全主动脉弓置换加冷冻象鼻技术(TAR 加 FET)治疗急性 DeBakey Ⅰ型主动脉夹层的短期疗效。

方法

回顾性分析 2017 年 1 月至 2019 年 6 月在单一中心接受治疗的急性 DeBakey Ⅰ型主动脉夹层患者的临床资料,HAR 组 92 例,TAR 加 FET 组 268 例,采用倾向评分匹配 56 对。

结果

匹配后,复合终点(30 天死亡率、卒、截瘫、肾衰竭、肝衰竭、再次插管或气管切开和低心排综合征)无显著差异(HAR 组 21.4%,56 例中有 12 例;TAR 加 FET 组 21.4%,56 例中有 12 例,P=1.000)。HAR 组急性肾损伤(AKI)发生率显著低于 TAR 加 FET 组(58.9%,33/56 比 80.4%,45/56,P=0.031)。根据肾脏病改善全球结局标准,AKI 分期分布不同(P=0.039),TAR 加 FET 组高分级 AKI 患者更多。多变量逻辑分析显示,术式(HAR 或 TAR 加 FET)不是复合不良事件或卒的独立预测因子。HAR 是 AKI 的保护因素(比值比 0.485,95%置信区间 0.287-0.822;P=0.007)。

结论

在急性 DeBakey Ⅰ型主动脉夹层的治疗中,两组早期结果无显著差异,但 HAR 与 AKI 发生率显著降低相关。

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