雷公藤叶中的生物活性倍半萜多元醇酯

Bioactive sesquiterpene polyol esters from the leaves of Tripterygium wilfordii.

作者信息

Wang Chao, Li Chuang-Jun, Ma Jie, Yang Jing-Zhi, Chen Xiao-Guang, Hou Qi, Zhang Dong-Ming

机构信息

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; College of Pharmacy, Dalian Medical University, Dalian 116044, China.

出版信息

Fitoterapia. 2014 Jul;96:103-8. doi: 10.1016/j.fitote.2014.04.014. Epub 2014 Apr 18.

DOI:10.1016/j.fitote.2014.04.014

PMID:24752142

Abstract

Tripterygium wilfordii, a member of Celastraceae family, has been used as a traditional plant insecticide and a medicinal plant. Phytochemical investigation of the leaves of T. wilfordii has resulted in the isolation of eight sesquiterpene polyol esters triptersinines M-T (1-8) and one sesquiterpene pyridine alkaloid (9). The structures of the compounds were elucidated on the basis of spectroscopic data analyses, including UV, IR, MS, and NMR experiments. The inhibitory effects on nitric oxide production in LPS-induced macrophages of 1-9 were also evaluated.

摘要

雷公藤是卫矛科植物，一直被用作传统的植物杀虫剂和药用植物。对雷公藤叶片进行植物化学研究，已分离出8种倍半萜多元醇酯雷公藤素M - T（1 - 8）和1种倍半萜吡啶生物碱（9）。通过紫外光谱（UV）、红外光谱（IR）、质谱（MS）和核磁共振（NMR）等光谱数据分析，阐明了这些化合物的结构。还评估了化合物1 - 9对脂多糖诱导的巨噬细胞中一氧化氮产生的抑制作用。