State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China.
Fitoterapia. 2012 Mar;83(2):343-7. doi: 10.1016/j.fitote.2011.11.013. Epub 2011 Dec 4.
Four new neolignans, wilfordiols A-D (1-4), together with five known compounds (5-9), were isolated from an aqueous extract of the dried leaves of Tripterygium wilfordii. Their structures were determined by spectroscopic methods, including 1D and 2D NMR, HRESIMS, and CD experiments. The anti-inflammation activities of compounds 1-9 were evaluated by the inhibitory effect on NO production, in vitro.
从三萜木薯叶的水提物中分离得到四个新的新木脂素化合物，即威尔福醇 A-D（1-4），以及五个已知化合物（5-9）。通过 1D 和 2D NMR、HRESIMS 和 CD 实验等光谱方法确定了它们的结构。通过体外抑制 NO 产生的作用，评估了化合物 1-9 的抗炎活性。
