ICMR-National Institute of Traditional Medicine, Nehru Nagar, Belagavi 590010, India; ICMR-Virus Unit, Infectious Diseases and Beliaghata General Hospital, 57 Dr Suresh Chandra Banerjee Road, Beliaghata, Kolkata, West Bengal 700010, India.
Department of Life Sciences, Presidency University, 86/1, College Street, Kolkata 700073, India.
Cytokine. 2018 Dec;112:52-62. doi: 10.1016/j.cyto.2018.06.028. Epub 2018 Jun 28.
Recent evidences indicate that change in cellular metabolic pathways can alter immune response and function of the host; emphasizing the role of metabolome in health and diseases. Human Herpes simplex virus type-1 (HSV-1) and type-2 (HSV-2) causes diseases from asymptomatic to highly prevalent oral and genital herpes, recurrent blisters or neurological complications. Immune responses against HSV are complex with delicate interplay between innate signaling pathways and adaptive immune responses. The innate response involves the induction of protective IFN-1; while Natural Killer (NK) cells and plasmacytoid Dendritic Cells (pDC) confer in vivo adaptive anti-HSV response along with humoral and cellular components in controlling infection and latency. Metabolic changes lead to up-/down-regulation of several cytokines and chemokines like IFN-γ, IL-2, IL-4, IL-10 and MIP1β in HSV infection and recurrences. Recently, the viral protein ICP0 has been identified as an attenuator of TLR signaling, that inhibit innate responses to HSV. This review will summarize the role of metabolome in innate and adaptive effectors in infection, pathogenesis and immune control of HSV, highlighting the delicate interplay between the metabolic changes and immunity.
最近的证据表明，细胞代谢途径的改变会影响宿主的免疫反应和功能；强调代谢组在健康和疾病中的作用。人类单纯疱疹病毒 1 型（HSV-1）和 2 型（HSV-2）引起从无症状到高度流行的口腔和生殖器疱疹、复发性水疱或神经并发症的疾病。针对 HSV 的免疫反应是复杂的，先天信号通路和适应性免疫反应之间存在微妙的相互作用。先天反应涉及保护性 IFN-1 的诱导；而自然杀伤 (NK) 细胞和浆细胞样树突状细胞 (pDC) 在体内赋予抗 HSV 的适应性反应，以及控制感染和潜伏的体液和细胞成分。代谢变化导致 HSV 感染和复发时几种细胞因子和趋化因子（如 IFN-γ、IL-2、IL-4、IL-10 和 MIP1β）的上调/下调。最近，病毒蛋白 ICP0 被鉴定为 TLR 信号的衰减子，可抑制 HSV 的先天反应。本综述将总结代谢组在 HSV 感染、发病机制和免疫控制中的先天和适应性效应器中的作用，强调代谢变化和免疫之间的微妙相互作用。
