Correll Darin J, Vlassakov Kamen V, Kissin Igor
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
J Anesth Hist. 2018 Apr;4(2):109-114. doi: 10.1016/j.janh.2018.03.003. Epub 2018 Mar 23.
The aim of this study was to determine how interest in various general anesthetics among the authors of academic publications changed over the past 50 years.
Publication-based academic interest were analyzed using specific scientometric indices: popularity index (PI), top journal selectivity index (TJSI), and index of change (IC). Terms used for searches were the names of drugs belonging to two pharmacological classes of general anesthetics - inhaled and intravenous. Only those that had a PI value > 2.0 during at least one of the 10 five-year periods, from 1967 to 2016, were selected.
The PI, an index of comparative popularity, reflects a consistent decline in academic interest over time in both classes of general anesthetics. Over the past 25 years, the PI of inhaled anesthetics decreased by 52 %, and that of intravenous anesthetics fell by 32%. At the same time, the PI of anesthesia management increased by 167%. Among individual anesthetics, the most impressive change was a profound decline in halothane's PI, from 22.9 in 1972-1976 to 0.5 in 2012-2016. The interest in halothane was gradually supplanted by that in new agents, initially by enflurane, followed by isoflurane and finally, sevoflurane. The next meaningful change was the gradual rise in sevoflurane's PI to surpass that of isoflurane. The most dramatic change among the PIs of intravenous anesthetics was associated with the introduction of propofol: an increase from 1.8 to its maximum of 13.6.
The study revealed a constant decline over time in academic interest in the pharmacological basis of general anesthesia relative to all fields of anesthesia combined.
本研究旨在确定在过去50年里，学术出版物作者对各种全身麻醉剂的兴趣是如何变化的。
使用特定的科学计量指标分析基于出版物的学术兴趣：流行指数（PI）、顶级期刊选择性指数（TJSI）和变化指数（IC）。搜索所用的术语是属于两类全身麻醉剂——吸入性和静脉注射性——的药物名称。仅选择那些在1967年至2016年的10个五年期至少一个期间内PI值>2.0的药物。
PI作为比较流行程度的指标，反映出随着时间推移，对这两类全身麻醉剂的学术兴趣持续下降。在过去25年里，吸入性麻醉剂的PI下降了52%，静脉注射性麻醉剂的PI下降了32%。与此同时，麻醉管理的PI增加了167%。在个别麻醉剂中，最显著的变化是氟烷的PI大幅下降，从1972 - 1976年的22.9降至2012 - 2016年的0.5。对氟烷的兴趣逐渐被对新型药物的兴趣所取代，最初是恩氟烷，随后是异氟烷，最后是七氟烷。下一个有意义的变化是七氟烷的PI逐渐上升并超过异氟烷。静脉注射性麻醉剂的PI中最显著的变化与丙泊酚的引入有关：从1.8增加到最高13.6。
该研究表明，相对于所有麻醉领域的总和，随着时间推移，对全身麻醉药理学基础的学术兴趣持续下降。
