Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, UK.
BMJ Open. 2018 Jun 30;8(6):e020113. doi: 10.1136/bmjopen-2017-020113.
Worldwide, millions of individuals are affected by neglected tropical diseases (NTDs). They are frequently the poorest and most marginalised members of society. Their living conditions, among other things, make them susceptible to such diseases. Historically, several large-scale treatment programmes providing mass drug administrations (MDAs) were carried out per single disease but over the last decade there has been an increasing trend towards co-implementation of MDA activities given the resources used for such programmes are often the same. The COUNTDOWN multicountry studies focus on scaled-up implementation of integrated control strategies against four diseases: lymphatic filariasis, onchocerciasis, schistosomiasis and soil-transmitted helminthiasis. The objective of the COUNTDOWN economic study is to assess the multicountry implementation of control interventions in terms of equity, impact and efficiency.
The health economic study uses different analytical methods to assess the relationship between NTDs and poverty and the cost-effectiveness of different large-scale intervention options. Regression analysis will be used to study the determinants of NTD occurrence, the impact of NTDs on poverty, factors that hinder access to MDAs and the effect of NTDs on quality-of-life of those affected, including disability. Cost-effectiveness analyses of various integration methods will be performed using health economic modelling to estimate the cost and programme impact of different integration options. Here, cost-effectiveness ratios will be calculated, including multivariate sensitivity analyses, using Bayesian analysis.
Ethics approval has been received both at the Liverpool School of Tropical Medicine and in all participating countries. Results of the various substudies will be presented for publication in peer-reviewed journals.
1 July 2016 to 30 June-October 2019.
在全球范围内，数以百万计的人受到被忽视的热带病（NTDs）的影响。他们通常是社会中最贫穷和最边缘化的成员。除其他外，他们的生活条件使他们容易感染此类疾病。历史上，针对单一疾病进行了多次大规模治疗计划，提供大规模药物管理（MDA），但在过去十年中，鉴于此类计划使用的资源往往相同，越来越倾向于共同实施 MDA 活动。COUNTDOWN 多国家研究侧重于针对四种疾病（淋巴丝虫病、盘尾丝虫病、血吸虫病和土源性蠕虫病）扩大实施综合控制策略。COUNTDOWN 经济研究的目的是根据公平性、影响和效率评估多国控制干预措施的实施情况。
健康经济研究使用不同的分析方法来评估 NTDs 与贫困之间的关系以及不同大规模干预选择的成本效益。回归分析将用于研究 NTD 发生的决定因素、NTDs 对贫困的影响、阻碍 MDA 获得的因素以及 NTDs 对受影响者生活质量（包括残疾）的影响。使用健康经济建模对各种整合方法进行成本效益分析，以估计不同整合选择的成本和计划影响。在这里，将使用贝叶斯分析计算成本效益比，包括多变量敏感性分析。
利物浦热带医学院和所有参与国家都已获得伦理批准。将在同行评议期刊上发表各种子研究的结果。
2016 年 7 月 1 日至 2019 年 6 月 30 日至 10 月。
