Rogler C E, Sherman M, Su C Y, Shafritz D A, Summers J, Shows T B, Henderson A, Kew M
Science. 1985 Oct 18;230(4723):319-22. doi: 10.1126/science.2996131.
Hepatitis B virus (HBV), a virus with known carcinogenic potential, integrates into cellular DNA during long-term persistent infection in man. Hepatocellular carcinomas isolated from viral carriers often contain clonally propagated viral DNA integrations. As small chromosomal deletions are associated with several types of carcinomas, the occurrence of chromosomal deletions in association with HBV integration in hepatocellular carcinoma was studied. HBV integration was accompanied by a deletion of at least 13.5 kilobases of cellular sequences in a human hepatocellular carcinoma. The viral DNA integration and deletion of cellular sequences occurred on the short arm of chromosome 11 at location 11p13-11p14. The cellular sequences that were deleted at the site of HBV integration were lost from the tumor cells, leaving only a single copy of the remaining cellular allele.
乙肝病毒（HBV）是一种具有已知致癌潜力的病毒，在人类长期持续感染期间会整合到细胞DNA中。从病毒携带者分离出的肝细胞癌通常含有克隆性传播的病毒DNA整合。由于小的染色体缺失与几种类型的癌症相关，因此研究了肝细胞癌中与HBV整合相关的染色体缺失的发生情况。在一例人类肝细胞癌中，HBV整合伴随着至少13.5千碱基细胞序列的缺失。病毒DNA整合和细胞序列缺失发生在11号染色体短臂的11p13 - 11p14位置。在HBV整合位点缺失的细胞序列从肿瘤细胞中丢失，仅留下剩余细胞等位基因的单拷贝。
