Liu Jia, Xu Longhai, Ma Xuefeng, Bi Yanzhen, Xin Yongning
School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, People's Republic of China.
Department of Infectious Diseases, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao, Shandong, People's Republic of China.
Hepat Med. 2025 Jul 18;17:39-59. doi: 10.2147/HMER.S526977. eCollection 2025.
Hepatitis B virus (HBV) infection is a global health concern, linked to chronic hepatitis, cirrhosis, and hepatocellular carcinoma. HBV genome integration into host DNA is critical in disease progression and oncogenesis. Despite advancements in understanding HBV pathogenesis and therapies, the mechanisms and implications of HBV integration remain unclear. This study employs bibliometric analysis to evaluate research trends and collaborations in HBV integration.
We utilized the Web of Science Core Collection (WOSCC) as our primary data source, meticulously screening and identifying 972 pertinent articles published between 1980 and November 30, 2024. Bibliometric tools, including VOSviewer, CiteSpace, and Bibliometrix, were employed to analyze publication trends, authorship, institutional contributions, and key research areas. Citation data and keyword clusters were examined to identify research hotspots.
Publications have steadily increased from 1980 to November 30, 2024, with China and the United States contributing the most studies. While China leads in publication volume, the United States has the highest citation impact. The Institut Pasteur in Paris ranks highest in publications. Hino O is the most prolific author, and Koike K the most cited. Hepatology is the most cited journal, and the article "Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma" is the most referenced. Cluster analysis revealed five major research themes.
This study highlights global research trends and key contributors in HBV integration, offering insights into current hotspots and future directions. The findings provide a basis for advancing diagnostic and therapeutic strategies targeting HBV integration.
乙型肝炎病毒（HBV）感染是一个全球关注的健康问题，与慢性肝炎、肝硬化和肝细胞癌相关。HBV基因组整合到宿主DNA中在疾病进展和肿瘤发生过程中至关重要。尽管在理解HBV发病机制和治疗方面取得了进展，但HBV整合的机制和影响仍不清楚。本研究采用文献计量分析来评估HBV整合领域的研究趋势和合作情况。
我们将科学网核心合集（WOSCC）作为主要数据源，精心筛选并识别出1980年至2024年11月30日期间发表的972篇相关文章。使用包括VOSviewer、CiteSpace和Bibliometrix在内的文献计量工具来分析出版趋势、作者情况、机构贡献和关键研究领域。通过检查引文数据和关键词聚类来识别研究热点。
从1980年到2024年11月30日，出版物数量稳步增加，中国和美国的研究贡献最多。虽然中国在出版物数量上领先，但美国的引文影响力最高。巴黎巴斯德研究所的出版物数量排名最高。日野雄是发文量最多的作者，小池克则是被引用次数最多的作者。《肝脏病学》是被引用次数最多的期刊，《肝细胞癌中复发性HBV整合的全基因组调查》这篇文章被引用得最多。聚类分析揭示了五个主要研究主题。
本研究突出了HBV整合领域的全球研究趋势和主要贡献者，深入了解了当前的热点和未来方向。研究结果为推进针对HBV整合的诊断和治疗策略提供了依据。
