Gupta S, Saverymuttu S H, Gibbs J S, Evans D J, Hodgson H J
Am J Gastroenterol. 1985 Nov;80(11):877-81.
An elderly man with thymoma, myasthenia gravis, and hypogammaglobulinemia developed profuse watery diarrhea. Infusions of gamma-globulin caused the diarrhea to resolve. The patient succumbed to fulminant bronchopneumonia. At necropsy he was found to have widespread cytomegalovirus infection with duodenal and ileal ulceration, subtotal villous atrophy, marked nonspecific inflammation of the small intestine and bronchopneumonia. In addition Herpes simplex infection and invasive candidiasis were present. Patients with immunodeficiency are susceptible to a variety of gastrointestinal pathogens, particularly viral.
一名患有胸腺瘤、重症肌无力和低丙种球蛋白血症的老年男性出现了大量水样腹泻。输注丙种球蛋白后腹泻缓解。患者最终死于暴发性支气管肺炎。尸检发现他患有广泛的巨细胞病毒感染，伴有十二指肠和回肠溃疡、绒毛部分萎缩、小肠明显的非特异性炎症以及支气管肺炎。此外，还存在单纯疱疹感染和侵袭性念珠菌病。免疫缺陷患者易感染多种胃肠道病原体，尤其是病毒。
