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一名既往健康儿童患隐球菌性脑膜炎。

Cryptococcal meningitis in a previously healthy child.

作者信息

Chimowa Takondwa, King Isobel, Iroh Tam Pui-Ying, Gonzalez-Martinez Carmen

机构信息

Department of Paediatrics, Queen Elizabeth Central Hospital, Blantyre, Malawi.

Mulanje Mission Hospital, Mulanje, Malawi.

出版信息

Malawi Med J. 2017 Dec;29(4):330-331. doi: 10.4314/mmj.v29i4.10.

DOI:10.4314/mmj.v29i4.10
PMID:29963290
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6019541/
Abstract

An 8-year-old previously healthy female presented with a 3 weeks history of headache, neck stiffness, deafness, fever and vomiting and was diagnosed with cryptococcal meningitis. She had documented hearing loss and was referred to tertiary-level care after treatment with fluconazole did not improve her neurological signs and symptoms. Her symptoms slowly resolved over two months. This case report illustrates the occurrence of cryptococcal meningitis in a non-immunocompromised patient, as well as the challenges of providing effective care in resource-limited settings.

摘要

一名8岁既往健康的女性,出现了为期3周的头痛、颈部僵硬、耳聋、发热和呕吐症状,被诊断为隐球菌性脑膜炎。她有听力损失记录,在使用氟康唑治疗后神经体征和症状未改善,遂被转诊至三级医疗机构。她的症状在两个月内逐渐缓解。本病例报告说明了非免疫功能低下患者中隐球菌性脑膜炎的发生情况,以及在资源有限的环境中提供有效护理所面临的挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84eb/6019541/712cc9e7a664/MMJ2904-0330Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84eb/6019541/712cc9e7a664/MMJ2904-0330Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84eb/6019541/712cc9e7a664/MMJ2904-0330Fig1.jpg

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本文引用的文献

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Characteristics and outcomes of cryptococcal meningitis in HIV seronegative children in Beijing, China, 2002-2013.2002年至2013年中国北京HIV血清阴性儿童隐球菌性脑膜炎的特征与转归
BMC Infect Dis. 2016 Nov 4;16(1):635. doi: 10.1186/s12879-016-1964-6.
2
Evolution of Cryptococcal Antigen Testing: What is new?隐球菌抗原检测的进展:有哪些新变化?
Curr Fungal Infect Rep. 2016 Jun;10(2):62-67. doi: 10.1007/s12281-016-0256-3. Epub 2016 Apr 12.
3
Management of Cryptococcus gattii meningoencephalitis.新型隐球菌性脑膜脑炎的治疗。
一名患有先天性心脏病儿童的新型隐球菌性脑膜炎罕见病例。
Case Rep Infect Dis. 2021 Jul 29;2021:9994804. doi: 10.1155/2021/9994804. eCollection 2021.
Lancet Infect Dis. 2015 Mar;15(3):348-55. doi: 10.1016/S1473-3099(14)70945-4. Epub 2014 Nov 26.
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Epidemiology of cryptococcal meningitis in the US: 1997-2009.美国隐球菌性脑膜炎的流行病学:1997-2009 年。
PLoS One. 2013;8(2):e56269. doi: 10.1371/journal.pone.0056269. Epub 2013 Feb 15.
5
Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS.对全球感染艾滋病毒/艾滋病者中隐球菌性脑膜炎当前负担的估计。
AIDS. 2009 Feb 20;23(4):525-30. doi: 10.1097/QAD.0b013e328322ffac.
6
Epidemiological profile of cryptococcal meningitis patients in Rio Grande do Sul, Brazil.巴西南里奥格兰德州隐球菌性脑膜炎患者的流行病学概况。
Mycopathologia. 2008 Aug;166(2):71-5. doi: 10.1007/s11046-008-9123-2. Epub 2008 Apr 29.