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美国首个全自动立体定向颅内放射外科旋转伽马射线装置的剂量测定与治疗描述

Dosimetry and Treatment Descriptions Using the First Completely Automated Stereotactic Intracranial Radiosurgery Rotating Gamma Ray Unit in America.

作者信息

Lovo Eduardo E, Campos Fidel J, Caceros Victor E, Minervini Mario H, Reyes William A

机构信息

Radiosurgery Program, Centro Internacional De Cancer, Hospital De Diagnostico, San Salvador, SLV.

出版信息

Cureus. 2018 Apr 27;10(4):e2542. doi: 10.7759/cureus.2542.

Abstract

Introduction The objective is to report the dosimetry and safety profiles of the first fully automatized rotating gamma ray unit for intracranial radiosurgery in America. Methods Dosimetry tests were conducted by our institution using the standard of examination and calibration and the Intelligent γ Radiometer of the China Research Institute of Measurement. The phantom and dosimetry tests were performed by the Outreach Physics Section of MD Anderson Cancer Center and the Anchorage Radiation Therapy Center using the Radiation Therapy Oncology Group (RTOG) radiosurgery quality assurance guidelines. Clinically, 233 patients were treated. Results Mechanical precision was 0.16 mm and the offset registered at the phantom on all axes was 0.0. The ratio of the dose to the center was 0.97 (0.95-1.05), the ratio of the treated volume was 0.95 (0.75-1.25), the ratio of the measured treated volume to the volume of the target was 1.29 (1.00-2.00), the ratio of the minimal dose to the dose prescribed was 1.05 (>0.90), with a treated volume of 0.95 (0.75-1.25) and a minimum dose to target of 1.05 (>0.90). The dose rate at loading was 3.89 Gy per minute. None of the patients treated experienced severe complications. Conclusions The dosimetry studies are compliant with quality assurance standards for intracranial radiosurgery.

摘要

引言 目的是报告美国首台用于颅内放射外科的全自动旋转伽马射线装置的剂量测定和安全性概况。方法 剂量测定测试由本机构按照检验和校准标准以及中国计量科学研究院的智能γ辐射计进行。模体和剂量测定测试由MD安德森癌症中心的外展物理科和安克雷奇放射治疗中心按照放射治疗肿瘤学组(RTOG)放射外科质量保证指南进行。临床上,对233例患者进行了治疗。结果 机械精度为0.16毫米,在模体上所有轴的偏移记录为0.0。中心剂量比为0.97(0.95 - 1.05),治疗体积比为0.95(0.75 - 1.25),测量的治疗体积与靶体积之比为1.29(1.00 - 2.00),最小剂量与处方剂量之比为1.05(>0.90),治疗体积为0.95(0.75 - 1.25),靶区最小剂量为1.05(>0.90)。加载时的剂量率为每分钟3.89戈瑞。接受治疗的患者均未出现严重并发症。结论 剂量测定研究符合颅内放射外科的质量保证标准。

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