Bhatnagar Jagdish P, Novotny Josef, Niranjan Ajay, Kondziolka Douglas, Flickinger John, Lunsford Dade, Huq M Saiful
Department of Radiation Oncology, Neurological Surgery, University of Pittsburgh Cancer Institute, Pittsburgh, USA.
J Med Phys. 2009 Jul;34(3):141-8. doi: 10.4103/0971-6203.54848.
A new model of Leksell Gamma Knife(R) (LGK), known as Perfexion (LGK PFX), was introduced by Elekta Instrument, AB, Sweden, in 2006. This model has a radically different design from the earlier models U, B, C and 4C. Dosimetric characteristics of LGK PFX, technical differences between LGK PFX and LGK 4C, experience gained with acceptance testing and commissioning of the LGK PFX, and comparison between LGK PFX and LGK 4C are presented in this study. Excellent agreement is found between the manufacturers recommended values of absorbed dose rate, relative output factors for 4 and 8 mm collimators, coincidence of mechanical and dosimetric isocenter, FWHM for beam profiles for various collimators and those reported in the present study. Excellent agreement is also found between the dosimetric characteristics of LGK PFX and LGK 4C for the 4 and 8 mm collimators. Examples of clinical cases treated with LGK PFX and impact of LGK PFX on workflow and dosimetric conformity of treatment planning is also given. The set up and treatment of patients on the LGK PFX is much more efficient since it is a fully automated system. The system also provides more options to generate plan with high dosimetric conformity.
2006年，瑞典医科达仪器有限公司（Elekta Instrument, AB）推出了一种新型的Leksell伽玛刀（LGK），即Perfexion型（LGK PFX）。该型号与早期的U型、B型、C型和4C型设计截然不同。本研究介绍了LGK PFX的剂量学特征、LGK PFX与LGK 4C之间的技术差异、LGK PFX验收测试和调试的经验，以及LGK PFX与LGK 4C的比较。研究发现，制造商推荐的吸收剂量率值、4毫米和8毫米准直器的相对输出因子、机械等中心和剂量学等中心的重合度、各种准直器束流剖面的半高宽，与本研究报告的值之间具有极好的一致性。LGK PFX和LGK 4C在4毫米和8毫米准直器的剂量学特征方面也具有极好的一致性。还给出了使用LGK PFX治疗的临床病例示例，以及LGK PFX对工作流程和治疗计划剂量学适形性的影响。由于LGK PFX是一个全自动系统，因此在该设备上对患者进行设置和治疗效率更高。该系统还提供了更多选项来生成具有高剂量学适形性的计划。
