Brooks R G, Hofflin J M, Jamieson S W, Stinson E B, Remington J S
Am J Med. 1985 Oct;79(4):412-22. doi: 10.1016/0002-9343(85)90027-0.
Infectious complications were studied in 14 patients who received heart-lung transplants at Stanford University Medical Center from March 1981 to November 1983. Twenty-nine infections occurred in 12 patients: 18 bacterial, nine viral, and two fungal. Sixteen (89 percent) of the bacterial infections occurred in the lung. Because of frequent colonization of the lower respiratory tract, the specificity of transtracheal aspiration and bronchoscopy was low. Empiric broad-spectrum antibiotic therapy was usually successful, and no patient died of bacterial infection. Cytomegalovirus infection occurred in six and herpes simplex virus infection in three patients. Two patients had invasive candidiasis at postmortem examination. This series emphasizes the importance of infection, particularly of the lung, in causing morbidity and mortality in heart-lung transplant recipients.
对1981年3月至1983年11月在斯坦福大学医学中心接受心肺移植的14例患者的感染并发症进行了研究。12例患者发生了29次感染：18次细菌感染、9次病毒感染和2次真菌感染。16次（89%）细菌感染发生在肺部。由于下呼吸道常有定植菌，经气管抽吸和支气管镜检查的特异性较低。经验性广谱抗生素治疗通常成功，没有患者死于细菌感染。6例发生巨细胞病毒感染，3例发生单纯疱疹病毒感染。2例患者尸检时有侵袭性念珠菌病。该系列研究强调了感染，尤其是肺部感染，在心肺移植受者发病和死亡中的重要性。
