Dummer J S, Montero C G, Griffith B P, Hardesty R L, Paradis I L, Ho M
Transplantation. 1986 Jun;41(6):725-9. doi: 10.1097/00007890-198606000-00012.
Infectious episodes were analyzed in 14 heart-lung transplant recipients who survived more than one week after transplantation. These patients had higher rates of infection than heart transplant recipients at our institution (P less than 0.01) and greater than 90% of all infections were potentially life-threatening. A total of 67% of all infections involved the lung or thoracic cavity as a primary site, and most of the rest were disseminated viral or fungal infections. Pneumocystis carinii infections occurred in six patients and were more common in this group than in patients who received heart transplants in the same period (P less than 0.005). Two patients followed more than one year developed a syndrome of chronic sputum production and bronchial colonization with Pseudomonas aeruginosa, which required recurrent treatment with i.v. antibiotics for symptomatic relief. The high rate of pulmonary infections in these patients presents a challenge to clinical management, and suggests that intensive and invasive monitoring for pulmonary infection is desirable.
对14例心肺移植受者移植后存活超过1周的感染发作情况进行了分析。这些患者的感染率高于我们机构的心脏移植受者（P<0.01），且超过90%的感染具有潜在生命危险。所有感染中，共有67%以肺部或胸腔作为主要感染部位，其余大部分为播散性病毒或真菌感染。卡氏肺孢子虫感染发生在6例患者中，在该组比同期接受心脏移植的患者更常见（P<0.005）。2例随访超过1年的患者出现慢性咳痰和支气管被铜绿假单胞菌定植的综合征，需要静脉使用抗生素反复治疗以缓解症状。这些患者肺部感染的高发生率对临床管理构成挑战，提示对肺部感染进行强化和侵入性监测是可取的。
